Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 12/20 | 0.48 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.39 |
| ▸ | INSR | P06213 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 2/20 | 0.39 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4538610 | 0.89 | LRRK2 (0.47) | EGFRLRRK2ALKINSR | |
| SCHEMBL18454684 | 0.87 | LRRK2 (0.44) | EGFRLRRK2ALKINSR | |
| SCHEMBL4539233 | 0.86 | LRRK2 (0.48) | EGFRLRRK2ALKINSR | |
| SCHEMBL5021360 | 0.85 | LRRK2 (0.64) | EGFRLRRK2ALK | |
| SCHEMBL21613957 | 0.85 | LRRK2 (0.45) | EGFRLRRK2ALKINSR | |
| SCHEMBL4542755 | 0.83 | LRRK2 (0.52) | LRRK2 | |
| SCHEMBL5021367 | 0.79 | EGFR (0.48) | EGFRLRRK2ALKINSRFLT3 | |
| SCHEMBL4537127 | 0.78 | LRRK2 (0.63) | EGFRLRRK2 | |
| SCHEMBL5021150 | 0.76 | LRRK2 (0.46) | EGFRLRRK2ALKINSR | |
| SCHEMBL4542112 | 0.75 | LRRK2 (0.52) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012062783-A1 | PYRAZOLE AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-05-18 | — | — | WO | disclosed |