Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 15/20 | 0.46 |
| ▸ | EGFR | P00533 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | INSR | P06213 | 1/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18426068 | 0.90 | LRRK2 (0.47) | LRRK2MAPK1INSRALK | |
| SCHEMBL4542329 | 0.85 | LRRK2 (0.46) | LRRK2EGFR | |
| SCHEMBL4562363 | 0.85 | LRRK2 (0.58) | LRRK2 | |
| SCHEMBL4537127 | 0.81 | LRRK2 (0.63) | LRRK2EGFRMAPK1 | |
| SCHEMBL27939108 | 0.81 | LRRK2 (0.43) | LRRK2MAPK1 | |
| SCHEMBL4542112 | 0.78 | LRRK2 (0.52) | LRRK2 | |
| SCHEMBL5021149 | 0.78 | LRRK2 (0.54) | LRRK2 | |
| SCHEMBL5021172 | 0.76 | EGFR (0.48) | LRRK2EGFRINSRALK | |
| SCHEMBL4531370 | 0.75 | LRRK2 (0.58) | LRRK2MAPK1INSRALK | |
| SCHEMBL4538610 | 0.75 | LRRK2 (0.47) | LRRK2EGFRINSRALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012062783-A1 | PYRAZOLE AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-05-18 | — | — | WO | disclosed |