Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 14/20 | 0.79 |
| ▸ | NR1I2 | O75469 | 4/20 | 0.79 |
| ▸ | RORA | P35398 | 4/20 | 0.79 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.79 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.79 |
| ▸ | RORB | Q92753 | 4/20 | 0.79 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.79 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5021887 | 0.91 | RORC (0.85) | RORCNR1I2RORANR1H2NR1H3 | |
| SCHEMBL5023110 | 0.91 | RORC (0.88) | RORCNR1I2RORANR1H2NR1H3 | |
| SCHEMBL5022225 | 0.90 | RORC (0.85) | RORCNR1I2RORANR1H2NR1H3 | |
| SCHEMBL15610924 | 0.89 | RORC (0.90) | RORCNR1I2RORANR1H2NR1H3 | |
| SCHEMBL4560678 | 0.89 | RORC (1.00) | RORCNR1I2RORANR1H2NR1H3 | |
| SCHEMBL5021889 | 0.89 | RORC (0.86) | RORCNR1I2RORANR1H2NR1H3 | |
| SCHEMBL5022254 | 0.88 | RORC (0.83) | RORCNR1I2RORANR1H2NR1H3 | |
| SCHEMBL15628902 | 0.87 | RORC (0.76) | RORCNR1I2RORANR1H2NR1H3 | |
| SCHEMBL5023492 | 0.87 | RORC (0.81) | RORCNR1I2RORANR1H2NR1H3 | |
| SCHEMBL15611524 | 0.87 | RORC (0.87) | RORCNR1I2RORANR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012064744-A2 | TETRAHYDROQUINOLINE AND RELATED BICYCLIC COMPOUNDS FOR INHIBITION OF RORϒ ACTIVITY AND THE TREATMENT OF DISEASE | LYCERA CORPORATION (US) | 2012-05-18 | — | — | WO | disclosed |