Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 14/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5021843 | 0.89 | GRM5 (0.67) | GRM5CYP2D6 | |
| SCHEMBL5021841 | 0.89 | GRM5 (0.67) | GRM5CYP2D6 | |
| SCHEMBL5022106 | 0.89 | GRM5 (0.67) | GRM5CYP2D6 | |
| SCHEMBL13642432 | 0.84 | GRM5 (0.54) | GRM5CYP2D6 | |
| SCHEMBL13642122 | 0.84 | GRM5 (0.71) | GRM5 | |
| SCHEMBL13642413 | 0.84 | GRM5 (0.71) | GRM5 | |
| SCHEMBL16363949 | 0.83 | GRM5 (0.81) | GRM5 | |
| SCHEMBL13642059 | 0.82 | GRM5 (0.52) | GRM5CYP2D6 | |
| SCHEMBL13642155 | 0.82 | GRM5 (0.52) | GRM5CYP2D6 | |
| SCHEMBL13642142 | 0.81 | GRM5 (0.52) | GRM5GAAHSD17B1HSD17B2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012064603-A1 | OXAZOLIDINONES AS MODULATORS OF MGLUR5 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-05-18 | — | — | WO | disclosed |