Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 5/20 | 0.58 |
| ▸ | NPC1 | O15118 | 5/20 | 0.58 |
| ▸ | RAB9A | P51151 | 5/20 | 0.58 |
| ▸ | CASP3 | P42574 | 1/20 | 0.58 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.58 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.58 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.51 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | MITF | O75030 | 1/20 | 0.49 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 6/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4064359 | 0.83 | NPC1 (0.57) | POLBNPC1RAB9ACASP3SENP8 | |
| SCHEMBL4189931 | 0.82 | KMT2A (0.73) | POLBNPC1RAB9AMEN1KMT2A | |
| SCHEMBL14037478 | 0.82 | POLB (0.52) | POLBNPC1RAB9ACASP3SENP8 | |
| Fluoride SCHEMBL11793913 | 0.80 | KMT2A (0.71) | POLBNPC1RAB9AMEN1KMT2A | |
| SCHEMBL28208041 | 0.80 | HTT (0.65) | POLBNPC1RAB9ACASP3SENP8 | |
| SCHEMBL4058023 | 0.79 | NPC1 (0.56) | POLBNPC1RAB9ACASP3SENP8 | |
| SCHEMBL3821099 | 0.78 | NQO1 (0.62) | NPC1MEN1KMT2ACYP1A2TDP1 | |
| SCHEMBL29779700 | 0.78 | NQO1 (0.62) | NPC1MEN1KMT2ACYP1A2TDP1 | |
| SCHEMBL14470413 | 0.78 | POLB (0.74) | POLBNPC1RAB9ACASP3SENP8 | |
| SCHEMBL3462939 | 0.77 | EGFR (0.66) | POLBNPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1687262-B1 | BICYCLIC AMIDE, CARBAMATE OR UREA DERIVATIVES AS VANILLOID RECEPTOR MODULATORS | BAYER HEALTHCARE AG (DE) | 2008-11-19 | — | — | EP | disclosed |
| US-20080058377-A1 | Bicyclic Amide, Carbamate or Urea Derivatives as Vanilloid Receptor Modulators | BAYER HEALTHCARE AG (DE) | 2008-03-06 | — | — | US | disclosed |
| EP-1687262-A1 | BICYCLIC AMIDE, CARBAMATE OR UREA DERIVATIVES AS VANILLOID RECEPTOR MODULATORS | Bayer HealthCare AG (DE) | 2006-08-09 | — | — | EP | disclosed |
| WO-2005044786-A1 | BICYCLIC AMIDE, CARBAMATE OR UREA DERIVATIVES AS VANILLOID RECEPTOR MODULATORS | BAYER HEALTHCARE AG (DE) | 2005-05-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080058377-A1 | Bicyclic Amide, Carbamate or Urea Derivatives as Vanilloid Receptor Modulators | NMUR1, CNR1, AVPR1A | POLB 3209/4885NPC1 1091/4885RAB9A 1723/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.