Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.52 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.48 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4358412 | 0.88 | KCNH2 (0.63) | KCNH2SLC6A2SLC6A3MEN1KMT2A | |
| SCHEMBL4203762 | 0.80 | KCNH2 (0.80) | KCNH2SLC6A2SLC6A3 | |
| SCHEMBL4214751 | 0.80 | KCNH2 (0.80) | KCNH2SLC6A2SLC6A3 | |
| SCHEMBL5022867 | 0.76 | KCNH2 (0.54) | KCNH2CYP2D6CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL5003316 | 0.75 | KMT2A (0.48) | ADRB2ADRB1ADRB3MEN1KMT2A | |
| SCHEMBL9655120 | 0.75 | KMT2A (0.67) | KCNH2ADRB2ADRB1ADRB3MEN1 | |
| SCHEMBL4196759 | 0.73 | KMT2A (0.53) | SLC6A2SLC6A3ADRB2ADRB1ADRB3 | |
| SCHEMBL4209781 | 0.72 | L3MBTL1 (0.51) | KCNH2SLC6A2SLC6A3ADRB2ADRB1 | |
| SCHEMBL4206039 | 0.71 | KCNH2 (0.64) | KCNH2SLC6A2SLC6A3ADRB2ADRB1 | |
| SCHEMBL4205925 | 0.71 | KCNH2 (0.64) | KCNH2SLC6A2SLC6A3ADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7375136-B2 | pH-dependent NMDA receptor antagonists | EMORY UNIVERSITY (US) | 2008-05-20 | — | — | US | disclosed |
| US-20040138502-A1 | Ph-dependent nmda receptor antagonists | EMORY UNIVERSITY | 2004-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040138502-A1 | Ph-dependent nmda receptor antagonists | GRIN1, GRIN2B, GRIN3A | KCNH2 382/4885SLC6A2 2030/4885SLC6A3 999/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.