Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.68 |
| ▸ | RAB9A | P51151 | 4/20 | 0.62 |
| ▸ | NPC1 | O15118 | 3/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.62 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.62 |
| ▸ | RELA | Q04206 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | PKM | P14618 | 3/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | GUCY1B2 | O75343 | 1/20 | 0.49 |
| ▸ | GUCY1A2 | P33402 | 1/20 | 0.49 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.49 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2177925 | 0.86 | MAPT (0.69) | MAPTRAB9ANPC1MAPK1NFKB1 | |
| SCHEMBL14465239 | 0.85 | MAPT (0.61) | MAPTRAB9ANPC1MAPK1NFKB1 | |
| SCHEMBL29241859 | 0.85 | MAPT (0.68) | MAPTRAB9ANPC1MAPK1NFKB1 | |
| SCHEMBL10815946 | 0.85 | MAPT (0.68) | MAPTRAB9ANPC1MAPK1NFKB1 | |
| SCHEMBL10812183 | 0.85 | MAPT (0.68) | MAPTRAB9ANPC1MAPK1NFKB1 | |
| SCHEMBL2177712 | 0.85 | MAPT (0.68) | MAPTRAB9ANPC1MAPK1NFKB1 | |
| SCHEMBL11435594 | 0.84 | MAPT (0.68) | MAPTRAB9ANPC1MAPK1NFKB1 | |
| SCHEMBL12970394 | 0.84 | MAPT (0.64) | MAPTRAB9ANPC1MAPK1NFKB1 | |
| SCHEMBL20603943 | 0.84 | MAPT (0.65) | MAPTRAB9ANPC1MAPK1NFKB1 | |
| SCHEMBL30826715 | 0.84 | MAPT (0.64) | MAPTRAB9ANPC1MAPK1NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449584-B2 | N-(2((4-Hydroxyphenyl)amino)pyridin-3-yl)-4-methoxybenzenesulfonamide Crystalline Form 1 | ABBOTT LABORATORIES INC. (US) | 2008-11-11 | — | — | US | disclosed |
| US-20070099967-A1 | causing nucleation in mixture with solvent between about 60 degrees C. and 100 degrees C., supersaturated; and isolating Crystalline Form 1 | ABBVIE INC. | 2007-05-03 | — | — | US | disclosed |
| WO-2006076511-A1 | N-(2-((4-HYDROXYPHENYL)AMINO)PYRIDIN-3-YL)-4-METHOXYBENZENESULFONAMIDE CRYSTALLINE FORM 1 | ABBOTT LABORATORIES (US) | 2006-07-20 | — | — | WO | disclosed |
| EP-0472053-B1 | Sulfonamide derivatives | EISAI CO LTD (JP) | 1998-06-17 | — | — | EP | disclosed |
| CN-1036650-C | process for the preparation of sulfonamide derivatives | EISAI CO LTD (JP) | 1997-12-10 | — | — | CN | disclosed |
| US-5610304-A | Pyrimidinyl or pyridinyl sulfonamide substituted compounds | EISAI CO., LTD. (JP) | 1997-03-11 | — | — | US | disclosed |
| US-5610320-A | ANTITUMOR AGENTS | EISAI CO., LTD. (JP) | 1997-03-11 | — | — | US | disclosed |
| CN-1136036-A | Sulfonamide derivatives | EISAI CO LTD (JP) | 1996-11-20 | — | — | CN | disclosed |
| US-5434172-A | Antitumor | EISAI CO., LTD. (JP) | 1995-07-18 | — | — | US | disclosed |
| US-5332751-A | Antitumor | EISAI CO., LTD. (JP) | 1994-07-26 | — | — | US | disclosed |
| US-5292758-A | Sulfonamide derivatives | EISAI CO., LTD. (JP) | 1994-03-08 | — | — | US | disclosed |
| US-5250549-A | Antitumor agents | EISAI CO., LTD. (JP) | 1993-10-05 | — | — | US | disclosed |
| CN-1059519-A | Sulfonamide derivatives | EISAI CO LTD (JP) | 1992-03-18 | — | — | CN | disclosed |
| EP-0472053-A2 | Sulfonamide derivatives | Eisai Co., Ltd. (JP) | 1992-02-26 | — | — | EP | disclosed |