Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 18/20 | 0.69 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5027425 | 0.88 | HRH3 (0.88) | HRH3HRH4 | |
| SCHEMBL5024288 | 0.87 | HRH3 (0.54) | HRH3HRH4AKR1C3 | |
| SCHEMBL5024117 | 0.85 | HRH3 (0.80) | HRH3HRH4 | |
| SCHEMBL5025867 | 0.83 | HRH3 (0.83) | HRH3HRH4 | |
| SCHEMBL5022340 | 0.83 | HRH3 (0.94) | HRH3 | |
| SCHEMBL1376118 | 0.83 | HRH3 (0.98) | HRH3 | |
| SCHEMBL3244462 | 0.82 | HRH3 (0.81) | HRH3HRH4 | |
| SCHEMBL5017002 | 0.82 | HRH3 (1.00) | HRH3 | |
| SCHEMBL5023645 | 0.82 | HRH3 (1.00) | HRH3 | |
| SCHEMBL3248126 | 0.81 | HRH3 (0.80) | HRH3HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761519-B1 | INDOLE DERIVATIVES AS HISTAMINE RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2008-05-07 | — | — | EP | disclosed |