Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 11/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5023252 | 0.87 | HRH3 (0.69) | HRH3HRH4AKR1C3 | |
| SCHEMBL3243347 | 0.83 | HRH3 (0.75) | HRH3 | |
| Hydrochloric Acid SCHEMBL1397957 | 0.82 | HRH3 (0.74) | HRH3 | |
| SCHEMBL5023593 | 0.81 | HRH3 (0.66) | HRH3KMT2A | |
| SCHEMBL5023289 | 0.81 | HRH3 (0.66) | HRH3KMT2A | |
| SCHEMBL5017160 | 0.78 | HRH3 (0.67) | HRH3 | |
| SCHEMBL19885959 | 0.75 | KMT2A (0.59) | HRH3KMT2AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL19885755 | 0.75 | KMT2A (0.59) | HRH3KMT2AKDM4EALDH1A1CYP1A2 | |
| Hydrochloric Acid SCHEMBL1397993 | 0.74 | HRH3 (0.56) | HRH3KMT2AAKR1C3 | |
| SCHEMBL5023558 | 0.74 | HRH3 (0.72) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761519-B1 | INDOLE DERIVATIVES AS HISTAMINE RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2008-05-07 | — | — | EP | disclosed |