Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.50 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.50 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TTR | P02766 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
| ▸ | PRKCA | P17252 | 4/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1583861 | 1.00 | HCAR2 (0.50) | HCAR2KEAP1NFE2L2MAPTALDH1A1 | |
| SCHEMBL10774158 | 0.94 | HCAR2 (0.48) | HCAR2KEAP1NFE2L2MAPTALDH1A1 | |
| SCHEMBL16293721 | 0.92 | HCAR2 (0.46) | HCAR2KEAP1NFE2L2MAPTALDH1A1 | |
| SCHEMBL19995666 | 0.92 | HCAR2 (0.46) | HCAR2KEAP1NFE2L2MAPTALDH1A1 | |
| SCHEMBL31378278 | 0.92 | HCAR2 (0.46) | HCAR2KEAP1NFE2L2MAPTALDH1A1 | |
| SCHEMBL25405291 | 0.92 | HCAR2 (0.46) | HCAR2KEAP1NFE2L2MAPTALDH1A1 | |
| SCHEMBL15500967 | 0.92 | HCAR2 (0.46) | HCAR2KEAP1NFE2L2MAPTALDH1A1 | |
| SCHEMBL16294102 | 0.92 | HCAR2 (0.46) | HCAR2KEAP1NFE2L2MAPTALDH1A1 | |
| SCHEMBL16294490 | 0.92 | HCAR2 (0.46) | HCAR2KEAP1NFE2L2MAPTALDH1A1 | |
| SCHEMBL16293722 | 0.92 | HCAR2 (0.46) | HCAR2KEAP1NFE2L2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945606-A1 | ALKYLCARBAMOYL NAPHTHALENYLOXY- OCTENOYLHYDROXYAMIDE DERIVATIVES HAVING INHIBITORY ACTIVITY AGAINST HISTONE DEACETYLASE AND PREPARATION THEREOF | Korea Research Institute of Chemical Technology (KR) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007052938-A1 | ALKYLCARBAMOYL NAPHTHALENYLOXY- OCTENOYLHYDROXYAMIDE DERIVATIVES HAVING INHIBITORY ACTIVITY AGAINST HISTONE DEACETYLASE AND PREPARATION THEREOF | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2007-05-10 | — | — | WO | disclosed |