Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.50 |
| ▸ | MGAM | O43451 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5023109 | 0.88 | KDM4E (0.55) | MAPTTP53TSHRMEN1USP2 | |
| SCHEMBL14364718 | 0.86 | MAPT (0.43) | MAPTTP53GAAMAPK1KMT2A | |
| SCHEMBL14277067 | 0.78 | KDM4E (0.52) | MAPTMEN1KMT2AKDM4EMCL1 | |
| SCHEMBL758464 | 0.75 | KDM4E (0.67) | MAPTTP53MAPK1KDM4EMCL1 | |
| SCHEMBL5026875 | 0.75 | KDM4E (0.51) | MAPTKMT2AKDM4EMCL1SMN1; SMN2 | |
| SCHEMBL6061022 | 0.73 | KDM4E (0.47) | MAPTKMT2AKDM4EMCL1SMN1; SMN2 | |
| SCHEMBL6953541 | 0.73 | RECQL (0.60) | MAPTTP53TSHRMEN1USP2 | |
| SCHEMBL5067315 | 0.71 | NPC1 (0.52) | MAPTTP53MEN1MAPK1KMT2A | |
| SCHEMBL5736871 | 0.71 | KDM4E (0.72) | MAPTTP53TSHRMEN1MAPK1 | |
| SCHEMBL206583 | 0.71 | HCRTR1 (0.66) | MAPTTSHRMEN1GAAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8486996-B2 | Aroylfuranes and aroylthiophenes | BASILEA PHARMACEUTICA AG (CH) | 2013-07-16 | — | — | US | disclosed |
| US-8486996-B2 | Aroylfuranes and aroylthiophenes | BASILEA PHARMACEUTICA AG (CH) | 2013-07-16 | — | — | US | disclosed |
| US-8486996-B2 | Aroylfuranes and aroylthiophenes | BASILEA PHARMACEUTICA AG (CH) | 2013-07-16 | — | — | US | disclosed |
| EP-1894917-A1 | Aryloxy- and arylthioxyacetophenone-type compounds for the treatment of cancer | Basilea Pharmaceutica AG (CH) | 2008-03-05 | — | — | EP | disclosed |
| EP-1894917-A1 | Aryloxy- and arylthioxyacetophenone-type compounds for the treatment of cancer | Basilea Pharmaceutica AG (CH) | 2008-03-05 | — | — | EP | disclosed |
| EP-1697336-B1 | AROYLFURANES AND AROYLTHIOPHENES SUITABLE FOR THE TREATMENT OF CANCER | BASILEA PHARMACEUTICA AG (CH) | 2007-12-19 | — | — | EP | disclosed |
| US-20060205739-A1 | Aroylfuranes and aroylthiophenes | BASILEA PHARMACEUTICA AG | 2006-09-14 | — | — | US | disclosed |
| EP-1697336-A2 | AROYLFURANES AND AROYLTHIOPHENES SUITABLE FOR THE TREATMENT OF CANCER | Basilea Pharmaceutica AG (CH) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005061476-A2 | AROYLFURANES AND AROYLTHIOPHENES | BASILEA PHARMACEUTICA AG (CH) | 2005-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060205739-A1 | Aroylfuranes and aroylthiophenes | TPMT, APRT, ABAT | MAPT 1505/4885TP53 401/4885TSHR 1612/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.