⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16353275 | 0.80 | CRBN (0.40) | — | |
| SCHEMBL18366453 | 0.77 | CRBN (0.37) | — | |
| SCHEMBL999429 | 0.69 | ADRA1A (0.32) | — | |
| SCHEMBL8272672 | 0.68 | GAA (0.34) | — | |
| SCHEMBL11170068 | 0.68 | BRD4 (0.42) | — | |
| SCHEMBL9267374 | 0.68 | KDR (0.46) | — | |
| SCHEMBL20719687 | 0.67 | — | — | |
| SCHEMBL11173756 | 0.66 | — | — | |
| SCHEMBL8088424 | 0.66 | — | — | |
| SCHEMBL25421399 | 0.65 | CRBN (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230210854-A1 | MONO- AND COMBINATION THERAPIES | RECURIUM IP HOLDINGS, LLC | 2023-07-06 | — | — | US | disclosed |
| US-20230008362-A1 | COMBINATIONS | RECURIUM IP HOLDINGS, LLC | 2023-01-12 | — | — | US | disclosed |
| CN-111032659-B | Imidazo [1, 2-a ] imidazol-2-one derivatives for the treatment of diseases such as parkinson's disease | 豪夫迈·罗氏有限公司 | 2022-09-09 | — | — | CN | disclosed |
| CN-111032659-B | Imidazo [1, 2-a ] imidazol-2-one derivatives for the treatment of diseases such as parkinson's disease | 豪夫迈·罗氏有限公司 | 2022-09-09 | — | — | CN | disclosed |
| US-20220024939-A1 | SUBSTITUTED 1,2-DIHYDRO-3H-PYRAZOLO[3,4-D]PYRIMIDIN-3-ONES | RECURIUM IP HOLDINGS, LLC | 2022-01-27 | — | — | US | disclosed |
| EP-3668873-A1 | IMIDAZO[1,2-A]IMIDAZOL-2-ONE DERIVATIVES FOR THE TREATMENT OF DISEASES SUCH AS PARKINSON'S DISEASE | H. Hoffnabb-La Roche Ag (CH) | 2020-06-24 | — | — | EP | disclosed |
| US-10590083-B2 | Pyridin-2-one derivatives of formula (I) useful as EP3 receptor antagonists | JANSSEN PHARMACEUTICA NV (BE) | 2020-03-17 | — | — | US | disclosed |
| US-10399944-B2 | Pyridin-2-one derivatives of formula (III) useful as EP3 receptor antagonists | JANSSEN PHARMACEUTICA NV (BE) | 2019-09-03 | — | — | US | disclosed |
| US-10336701-B2 | Pyridin-2-one derivatives of formula (II) useful as EP3 receptor antagonists | JANSSEN PHARMACEUTICA NV (BE) | 2019-07-02 | — | — | US | disclosed |
| WO-2019034713-A1 | IMIDAZO[1,2-A]IMIDAZOL-2-ONE DERIVATIVES FOR THE TREATMENT OF DISEASES SUCH AS PARKINSON'S DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2019-02-21 | — | — | WO | disclosed |
| EP-2445909-B1 | DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZO[1,2-a]IMIDAZOLE-3-CARBOXYLIC ACID AMIDES | BOEHRINGER INGELHEIM INT (DE) | 2013-11-13 | — | — | EP | disclosed |
| US-8575360-B2 | Derivatives of 6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-carboxylic acid amides | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-11-05 | — | — | US | disclosed |
| US-8481750-B2 | Derivatives of 6,7-dihydro-5H-imidazo[1,2-α]imidazole-3-carboxylic acid amides | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-07-09 | — | — | US | disclosed |
| US-20120252817-A1 | DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZO[1,2-a]IMIDAZOLE-3-CARBOXYLIC ACID AMIDES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-10-04 | — | — | US | disclosed |
| US-20120178734-A1 | DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZO[1,2-a]IMIDAZOLE-3-CARBOXYLIC ACID AMIDES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-07-12 | — | — | US | disclosed |
| US-7314940-B2 | For therapy and prophylaxis of neurodegenerative disorders related to apoptosis and/or inflammation | EISAI CO., LTD. (JP) | 2008-01-01 | — | — | US | disclosed |
| EP-1373269-B1 | JUN KINASE INHIBITORS | EISAI CO LTD (JP) | 2005-06-08 | — | — | EP | disclosed |
| US-20040235864-A1 | Jun kinase inhibitors | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2004-11-25 | — | — | US | disclosed |
| EP-1373269-A1 | JUN KINASE INHIBITORS | Eisai Co., Ltd. (JP) | 2004-01-02 | — | — | EP | disclosed |
| WO-2002081475-A1 | JUN KINASE INHIBITORS | EISAI CO., LIMITED (JP) | 2002-10-17 | — | — | WO | disclosed |