Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 7/20 | 0.43 |
| ▸ | PPARA | Q07869 | 7/20 | 0.43 |
| ▸ | PPARD | Q03181 | 6/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5024741 | 1.00 | PTPN1 (0.47) | PTPN1MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL5363966 | 0.90 | PTPN1 (0.45) | PTPN1MEN1KMT2APPARGPPARA | |
| SCHEMBL14854834 | 0.86 | PLA2G4B (0.44) | PTPN1MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL6698814 | 0.86 | PTPN1 (0.47) | PTPN1MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL5357749 | 0.85 | ITGB1 (0.43) | PTPN1MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL8763598 | 0.85 | PTPN1 (0.47) | PTPN1MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL7298611 | 0.85 | PTPN1 (0.47) | PTPN1MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL14855324 | 0.84 | PTGS2 (0.44) | PTPN1LMNAPPARGPPARANPC1 | |
| SCHEMBL6701409 | 0.84 | KMT2A (0.45) | PTPN1MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL14285180 | 0.82 | PPARA (0.51) | MEN1KMT2AALDH1A1LMNAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7321056-B2 | Selective peroxisome proliferator activated receptor modulators | ELI LILLY AND COMPANY (US) | 2008-01-22 | — | — | US | disclosed |
| EP-1697306-B1 | SELECTIVE PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR MODULATORS | LILLY CO ELI (US) | 2007-07-25 | — | — | EP | disclosed |
| US-20070066683-A1 | Selective peroxisome proliferator activated receptor modulators | ELI LILLY AND COMPANY | 2007-03-22 | — | — | US | disclosed |
| EP-1697306-A1 | SELECTIVE PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005061441-A1 | SELECTIVE PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070066683-A1 | Selective peroxisome proliferator activated receptor modulators | PPARG, PPARD, PPARA | PTPN1 1763/4885MEN1 4850/4885KMT2A 3261/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.