Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 3/20 | 0.54 |
| ▸ | PKM | P14618 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | RECQL | P46063 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | RGS12 | O14924 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | CASP1 | P29466 | 1/20 | 0.54 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.54 |
| ▸ | THPO | P40225 | 1/20 | 0.54 |
| ▸ | CASP7 | P55210 | 1/20 | 0.54 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5024795 | 0.79 | KDM4E (0.53) | USP2PKMPOLBALOX15HIF1A | |
| SCHEMBL30037334 | 0.79 | SLC7A5 (0.61) | USP2PKMPOLBALOX15HIF1A | |
| SCHEMBL3059437 | 0.79 | SLC7A5 (0.61) | USP2PKMPOLBALOX15HIF1A | |
| SCHEMBL4943107 | 0.79 | SLC7A5 (0.61) | USP2PKMPOLBALOX15HIF1A | |
| SCHEMBL2855498 | 0.78 | POLB (0.63) | PKMPOLBKDM4ETDP1CYP3A4 | |
| SCHEMBL5024792 | 0.78 | CYP3A4 (0.51) | USP2PKMPOLBALOX15HIF1A | |
| SCHEMBL2028058 | 0.77 | KDM4E (0.62) | USP2PKMPOLBALOX15HIF1A | |
| SCHEMBL2028643 | 0.77 | KDM4E (0.62) | USP2PKMPOLBALOX15HIF1A | |
| SCHEMBL2028640 | 0.77 | KDM4E (0.62) | USP2PKMPOLBALOX15HIF1A | |
| SCHEMBL2679928 | 0.77 | KDM4E (0.66) | USP2PKMPOLBALOX15HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012058325-A1 | COMPOUNDS AND METHODS USEFUL FOR TREATMENT OF DISEASES MEDIATED BY HIF-1 | ONCOTHYREON INC. (US) | 2012-05-03 | — | — | WO | disclosed |
| WO-2011057220-A2 | COMPOSITIONS AND METHODS FOR TREATING LYMPHOMA | NORTHWESTERN UNIVERSITY (US) | 2011-05-12 | — | — | WO | disclosed |