Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 6/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | PMP22 | Q01453 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | USP2 | O75604 | 3/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.51 |
| ▸ | BLM | P54132 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | RECQL | P46063 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | THPO | P40225 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5024795 | 0.88 | KDM4E (0.53) | CYP3A4ALOX15KDM4EHIF1AALDH1A1 | |
| SCHEMBL2729059 | 0.79 | HIF1A (0.56) | CYP3A4ALOX15KDM4EHIF1AALDH1A1 | |
| SCHEMBL2729020 | 0.79 | HIF1A (0.56) | CYP3A4ALOX15KDM4EHIF1AALDH1A1 | |
| SCHEMBL1897294 | 0.79 | HIF1A (0.56) | CYP3A4ALOX15KDM4EHIF1AALDH1A1 | |
| SCHEMBL5024800 | 0.78 | USP2 (0.54) | CYP3A4ALOX15KDM4EHIF1AALDH1A1 | |
| Hydrochloric Acid SCHEMBL28269560 | 0.77 | HIF1A (0.55) | CYP3A4ALOX15KDM4EHIF1AALDH1A1 | |
| Hydrochloric Acid SCHEMBL28267946 | 0.77 | HIF1A (0.55) | CYP3A4ALOX15KDM4EHIF1AALDH1A1 | |
| Hydrochloric Acid SCHEMBL28267943 | 0.77 | HIF1A (0.55) | CYP3A4ALOX15KDM4EHIF1AALDH1A1 | |
| Hydrochloric Acid SCHEMBL28269559 | 0.77 | HIF1A (0.55) | CYP3A4ALOX15KDM4EHIF1AALDH1A1 | |
| SCHEMBL2729253 | 0.77 | NOS3 (0.57) | CYP3A4ALOX15KDM4EHIF1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012058325-A1 | COMPOUNDS AND METHODS USEFUL FOR TREATMENT OF DISEASES MEDIATED BY HIF-1 | ONCOTHYREON INC. (US) | 2012-05-03 | — | — | WO | disclosed |
| WO-2011057220-A2 | COMPOSITIONS AND METHODS FOR TREATING LYMPHOMA | NORTHWESTERN UNIVERSITY (US) | 2011-05-12 | — | — | WO | disclosed |