Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.46 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13965438 | 0.95 | HCRTR1 (0.51) | SPHK2L3MBTL1HCRTR1HCRTR2HPGD | |
| SCHEMBL4931440 | 0.86 | SPHK2 (0.64) | SPHK2L3MBTL1POLBHCRTR1HCRTR2 | |
| SCHEMBL11447207 | 0.86 | SPHK2 (0.64) | SPHK2L3MBTL1POLBHCRTR1HCRTR2 | |
| SCHEMBL17888415 | 0.85 | GAA (0.49) | POLBHPGDALDH1A1KDM4E | |
| SCHEMBL968549 | 0.85 | HPGD (0.49) | SPHK2L3MBTL1POLBCHRNB2CHRNA7 | |
| SCHEMBL968551 | 0.85 | HPGD (0.49) | SPHK2L3MBTL1POLBCHRNB2CHRNA7 | |
| SCHEMBL12947819 | 0.85 | GAA (0.49) | POLBHPGDALDH1A1KDM4E | |
| SCHEMBL8253033 | 0.84 | NPC1 (0.54) | SPHK2L3MBTL1CHRNB2CHRNA5CHRNA7 | |
| SCHEMBL8253035 | 0.84 | NPC1 (0.54) | SPHK2L3MBTL1CHRNB2CHRNA5CHRNA7 | |
| SCHEMBL4932563 | 0.84 | SPHK2 (0.50) | SPHK2L3MBTL1POLBHCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1385845-B1 | N-AROYL CYCLIC AMINES | SMITHKLINE BEECHAM PLC (GB) | 2008-01-09 | — | — | EP | disclosed |