Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 3/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.50 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.50 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | VNN1 | O95497 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11447207 | 1.00 | SPHK2 (0.64) | SPHK2POLBL3MBTL1PDK2MEN1 | |
| SCHEMBL17600738 | 0.95 | SPHK2 (0.59) | SPHK2POLBL3MBTL1PDK2MEN1 | |
| SCHEMBL17600741 | 0.95 | SPHK2 (0.59) | SPHK2POLBL3MBTL1PDK2MEN1 | |
| SCHEMBL8341295 | 0.91 | SPHK2 (0.62) | SPHK2POLBL3MBTL1PDK2MEN1 | |
| SCHEMBL8243019 | 0.86 | NPC1 (0.54) | SPHK2L3MBTL1MEN1KMT2ARAB9A | |
| SCHEMBL4932563 | 0.86 | SPHK2 (0.50) | SPHK2POLBL3MBTL1PDK2HCRTR1 | |
| SCHEMBL8253035 | 0.86 | NPC1 (0.54) | SPHK2L3MBTL1MEN1KMT2ARAB9A | |
| SCHEMBL8253033 | 0.86 | NPC1 (0.54) | SPHK2L3MBTL1MEN1KMT2ARAB9A | |
| SCHEMBL5024926 | 0.86 | SPHK2 (0.50) | SPHK2POLBL3MBTL1HCRTR1HCRTR2 | |
| SCHEMBL8633642 | 0.86 | HCRTR1 (0.53) | SPHK2POLBL3MBTL1PDK2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11053195-B2 | Compounds and uses thereof for the modulation of hemoglobin | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-07-06 | — | — | US | disclosed |
| US-11053195-B2 | Compounds and uses thereof for the modulation of hemoglobin | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-07-06 | — | — | US | disclosed |
| EP-2970196-B1 | COMPOUNDS AND USES THEREOF FOR THE MODULATION OF HEMOGLOBIN | GLOBAL BLOOD THERAPEUTICS INC (US) | 2020-11-25 | — | — | EP | disclosed |
| CN-108404979-B | Thiourea-proline chiral catalyst and synthesis method and application thereof | 郑州轻工业学院 | 2020-07-17 | — | — | CN | disclosed |
| US-10450269-B1 | Compounds and uses thereof for the modulation of hemoglobin | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2019-10-22 | — | — | US | disclosed |
| US-10450269-B1 | Compounds and uses thereof for the modulation of hemoglobin | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2019-10-22 | — | — | US | disclosed |
| US-20190300477-A1 | COMPOUNDS AND USES THEREOF FOR THE MODULATION OF HEMOGLOBIN | GLOBAL BLOOD THERAPEUTICS, INC. | 2019-10-03 | — | — | US | disclosed |
| US-20190202782-A1 | COMPOUNDS AND USES THEREOF FOR THE MODULATION OF HEMOGLOBIN | GLOBAL BLOOD THERAPEUTICS, INC. | 2019-07-04 | — | — | US | disclosed |
| US-20190202782-A1 | COMPOUNDS AND USES THEREOF FOR THE MODULATION OF HEMOGLOBIN | GLOBAL BLOOD THERAPEUTICS, INC. | 2019-07-04 | — | — | US | disclosed |
| US-20190010121-A1 | COMPOUNDS AND USES THEREOF FOR THE MODULATION OF HEMOBLOGIN | GLOBAL BLOOD THERAPEUTICS, INC. | 2019-01-10 | — | — | US | disclosed |
| EP-0965585-A1 | Anti-amnesic thiazolidine derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 1999-12-22 | — | — | EP | disclosed |
| EP-0537802-B1 | N-acylpyrrolidines, process for their preparation and their use for prevention and/or treatment of amnesia | ONO PHARMACEUTICAL CO (JP) | 1999-08-25 | — | — | EP | disclosed |
| US-5545657-A | 1-ALKYLOYLPYRROLIDIN-2-YLOXOALKANOIC ACIDS AND DERIVATIVES; ANTIAMNESIA AGENTS; INHIBITORS OF PROLYL ENDOPEPTIDASE; SUPPRESSION OF NEUROTRANSMITTER METABOLISM | ONO PHARMACEUTICAL CO., LTD. (JP) | 1996-08-13 | — | — | US | disclosed |
| US-5411974-A | Thiazoline derivatives, treatment of amnesia | ONO PHARMACEUTICAL CO., LTD. (JP) | 1995-05-02 | — | — | US | disclosed |
| US-5401760-A | Thiazoline derivative for treating amnesia | ONO PHARMACEUTICAL CO., LTD. (JP) | 1995-03-28 | — | — | US | disclosed |
| EP-0345428-B1 | Anti-amnesic pyrrolidine derivatives | ONO PHARMACEUTICAL CO (JP) | 1995-01-18 | — | — | EP | disclosed |
| US-5212191-A | Thiazoline derivatives for treatment of amnesia | ONO PHARMACEUTICAL CO., LTD. (JP) | 1993-05-18 | — | — | US | disclosed |
| EP-0537802-A2 | N-acylpyrrolidines and N-acylthiazolidines, process for their preparation and their use for prevention and/or treatment of amnesia | ONO PHARMACEUTICAL CO., LTD. (JP) | 1993-04-21 | — | — | EP | disclosed |
| US-5053414-A | Thiazolidine derivatives, enzyme inhibitors; amnesia | ONO PHARMACEUTICAL CO., LTD. (JP) | 1991-10-01 | — | — | US | disclosed |
| EP-0345428-A1 | Anti-amnesic pyrrolidine derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 1989-12-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10450269-B1 | Compounds and uses thereof for the modulation of hemoglobin | HBG2, HBG1, HBB | SPHK2 974/4885POLB 3375/4885L3MBTL1 3065/4885 |
| US-11053195-B2 | Compounds and uses thereof for the modulation of hemoglobin | HBG2, HBG1, HBB | SPHK2 977/4885POLB 3494/4885L3MBTL1 2996/4885 |
| US-20190300477-A1 | COMPOUNDS AND USES THEREOF FOR THE MODULATION OF HEMOGLOBIN | HBG2, HBG1, HBB | SPHK2 974/4885POLB 3375/4885L3MBTL1 3065/4885 |
| US-20190202782-A1 | COMPOUNDS AND USES THEREOF FOR THE MODULATION OF HEMOGLOBIN | HBG2, HBG1, HBB | SPHK2 977/4885POLB 3494/4885L3MBTL1 2996/4885 |
| US-20190010121-A1 | COMPOUNDS AND USES THEREOF FOR THE MODULATION OF HEMOBLOGIN | HBG2, HBG1, HBB | SPHK2 987/4885POLB 3832/4885L3MBTL1 2138/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.