Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 8/20 | 0.73 |
| ▸ | ABL1 | P00519 | 8/20 | 0.68 |
| ▸ | CSF1R | P07333 | 5/20 | 0.67 |
| ▸ | KIT | P10721 | 5/20 | 0.67 |
| ▸ | EGFR | P00533 | 6/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | RAD52 | P43351 | 1/20 | 0.65 |
| ▸ | ATM | Q13315 | 1/20 | 0.65 |
| ▸ | LYN | P07948 | 3/20 | 0.64 |
| ▸ | BCR | P11274 | 3/20 | 0.64 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.64 |
| ▸ | LCK | P06239 | 1/20 | 0.64 |
| ▸ | FYN | P06241 | 1/20 | 0.64 |
| ▸ | YES1 | P07947 | 1/20 | 0.64 |
| ▸ | HCK | P08631 | 1/20 | 0.64 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.64 |
| ▸ | FGR | P09769 | 1/20 | 0.64 |
| ▸ | PIM1 | P11309 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3561586 | 0.97 | KIT (0.71) | BRAFABL1CSF1RKITEGFR | |
| Hydrochloric Acid SCHEMBL6014047 | 0.96 | KIT (0.70) | BRAFABL1CSF1RKITEGFR | |
| SCHEMBL4830586 | 0.90 | KIT (0.77) | BRAFABL1CSF1RKITEGFR | |
| SCHEMBL14286285 | 0.90 | ABL1 (0.71) | BRAFABL1CSF1RKITEGFR | |
| SCHEMBL13349541 | 0.88 | ABL1 (0.68) | BRAFABL1CSF1RKITEGFR | |
| SCHEMBL6431039 | 0.88 | ABL1 (0.70) | BRAFABL1CSF1RKITEGFR | |
| SCHEMBL5023760 | 0.85 | ABL1 (0.58) | BRAFABL1CSF1RKITEGFR | |
| SCHEMBL715899 | 0.85 | KIT (0.85) | BRAFABL1CSF1RKITEGFR | |
| SCHEMBL22024635 | 0.85 | BRAF (0.69) | BRAFABL1CSF1RKITEGFR | |
| SCHEMBL22025360 | 0.85 | BRAF (0.69) | BRAFABL1CSF1RKITEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080039466-A1 | 2-(3-Substituted-Aryl) Amino-4-Aryl-Thiazoles As Tyrosine Kinase Inhibitors | AB SCIENCE | 2008-02-14 | — | — | US | claimed |
| CN-1934107-A | 2- (3-substituted aryl) amino-4-aryl-thiazoles as tyrosine kinase inhibitors | AB SCIENCE (FR) | 2007-03-21 | — | — | CN | claimed |
| EP-1711497-A1 | 2-(3-SUBSTITUTED-ARYL)AMINO-4-ARYL-THIAZOLES AS TYROSINE KINASE INHIBITORS | AB Science (FR) | 2006-10-18 | — | — | EP | claimed |
| WO-2005073225-A1 | 2-(3-SUBSTITUTED-ARYL)AMINO-4-ARYL-THIAZOLES AS TYROSINE KINASE INHIBITORS | AB SCIENCE (FR) | 2005-08-11 | — | — | WO | claimed |
| US-20080039466-A1 | 2-(3-Substituted-Aryl) Amino-4-Aryl-Thiazoles As Tyrosine Kinase Inhibitors | AB SCIENCE | 2008-02-14 | — | — | US | disclosed |
| US-20080039466-A1 | 2-(3-Substituted-Aryl) Amino-4-Aryl-Thiazoles As Tyrosine Kinase Inhibitors | AB SCIENCE | 2008-02-14 | — | — | US | disclosed |
| US-20080039466-A1 | 2-(3-Substituted-Aryl) Amino-4-Aryl-Thiazoles As Tyrosine Kinase Inhibitors | AB SCIENCE | 2008-02-14 | — | — | US | disclosed |
| CN-1934107-A | 2- (3-substituted aryl) amino-4-aryl-thiazoles as tyrosine kinase inhibitors | AB SCIENCE (FR) | 2007-03-21 | — | — | CN | disclosed |
| EP-1711497-A1 | 2-(3-SUBSTITUTED-ARYL)AMINO-4-ARYL-THIAZOLES AS TYROSINE KINASE INHIBITORS | AB Science (FR) | 2006-10-18 | — | — | EP | disclosed |
| WO-2005073225-A1 | 2-(3-SUBSTITUTED-ARYL)AMINO-4-ARYL-THIAZOLES AS TYROSINE KINASE INHIBITORS | AB SCIENCE (FR) | 2005-08-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080039466-A1 | 2-(3-Substituted-Aryl) Amino-4-Aryl-Thiazoles As Tyrosine Kinase Inhibitors | KIT, MAP3K2, RET | BRAF 35/4885ABL1 22/4885CSF1R 307/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.