SCHEMBL5025879

SCHEMBL5025879

NCCN(CCN)C(=O)C[C@H](N)C(=O)N[C@@H](CCc1ccc2ccccc2c1)C(=O)Nc1cnc2ccccc2c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BDKRB2 P30411 1/20 0.46
HDAC1 Q13547 6/20 0.42
HDAC4 P56524 4/20 0.42
HDAC3 O15379 3/20 0.42
HDAC7 Q8WUI4 3/20 0.42
HDAC2 Q92769 3/20 0.42
HDAC10 Q969S8 3/20 0.42
HDAC11 Q96DB2 3/20 0.42
HDAC8 Q9BY41 3/20 0.42
HDAC6 Q9UBN7 3/20 0.42
HDAC9 Q9UKV0 3/20 0.42
HDAC5 Q9UQL6 3/20 0.42
RAB9A P51151 2/20 0.41
LMNA P02545 1/20 0.41
POLB P06746 1/20 0.41
TSHR P16473 1/20 0.41
HSD17B10 Q99714 1/20 0.41
TRPV1 Q8NER1 7/20 0.41
ACP1 P24666 1/20 0.39
KDM4E B2RXH2 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5018124 0.93 HDAC1 (0.44) BDKRB2HDAC1HDAC4HDAC3HDAC7
SCHEMBL5018201 0.93 HDAC1 (0.44) BDKRB2HDAC1HDAC4HDAC3HDAC7
SCHEMBL5018102 0.93 HDAC1 (0.44) BDKRB2HDAC1HDAC4HDAC3HDAC7
SCHEMBL5018359 0.89 HDAC1 (0.43) BDKRB2HDAC1HDAC4HDAC3HDAC7
SCHEMBL5018154 0.88 HDAC1 (0.45) HDAC1HDAC4HDAC3HDAC7HDAC2
SCHEMBL5018241 0.87 HDAC1 (0.46) HDAC1HDAC4HDAC3HDAC7HDAC2
SCHEMBL5018399 0.87 HDAC1 (0.44) BDKRB2HDAC1HDAC4HDAC3HDAC7
SCHEMBL13991926 0.86 SCN9A (0.47) BDKRB2HDAC1HDAC4HDAC3HDAC7
SCHEMBL5018464 0.85 RAB9A (0.42) HDAC1HDAC4HDAC3HDAC7HDAC2
SCHEMBL5018255 0.85 TRPV1 (0.44) HDAC1HDAC4HDAC3HDAC7HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8178490-B2 Polybasic bacterial efflux pump inhibitors and therapeutic uses thereof REMPEX PHARMACEUTICALS, INC. (US) 2012-05-15 US disclosed