SCHEMBL5025932

SCHEMBL5025932

Cc1ccc(C(C)(C)C)c(Nc2ccccc2O)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.48
ALDH1A1 P00352 1/20 0.48
TDP1 Q9NUW8 1/20 0.48
L3MBTL1 Q9Y468 1/20 0.46
GAA P10253 5/20 0.43
MEN1 O00255 3/20 0.43
KMT2A Q03164 3/20 0.43
MAPT P10636 3/20 0.43
CYP1A2 P05177 1/20 0.43
CYP3A4 P08684 1/20 0.43
CYP2D6 P10635 1/20 0.43
CYP2C9 P11712 1/20 0.43
CYP2C19 P33261 1/20 0.43
CXCR2 P25025 2/20 0.42
KCNMA1 Q12791 3/20 0.42
POLB P06746 1/20 0.42
HSD17B2 P37059 1/20 0.40
LMNA P02545 1/20 0.40
RAB9A P51151 1/20 0.40
HSD17B10 Q99714 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2165676 0.75 GAA (0.42) TSHRALDH1A1TDP1L3MBTL1GAA
SCHEMBL28494201 0.75 ALDH1A1 (0.53) TSHRALDH1A1TDP1L3MBTL1GAA
SCHEMBL23793635 0.73 TSHR (0.44) TSHRALDH1A1TDP1L3MBTL1GAA
SCHEMBL15485283 0.72 ALDH1A1 (0.59) TSHRALDH1A1TDP1GAAMEN1
SCHEMBL29362726 0.72 ALDH1A1 (0.59) TSHRALDH1A1TDP1GAAMEN1
SCHEMBL180815 0.72 ALDH1A1 (0.59) TSHRALDH1A1TDP1GAAMEN1
SCHEMBL304891 0.72 CXCR2 (0.54) ALDH1A1TDP1L3MBTL1GAAMEN1
SCHEMBL28360581 0.71 ALDH1A1 (0.53) TSHRALDH1A1TDP1L3MBTL1GAA
Hydrogen Sulfide SCHEMBL28854683 0.70 ALDH1A1 (0.56) TSHRALDH1A1TDP1GAAMEN1
Potassium SCHEMBL29477970 0.70 ALDH1A1 (0.56) TSHRALDH1A1TDP1GAAMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7267914-B2 Electrophotographic photoconductor, process cartridge, image forming apparatus and image forming method RICOH COMPANY, LTD. (JP) 2007-09-11 US claimed
US-7348115-B2 Electrophotographic photoconductor, process cartridge, image forming apparatus and image forming method RICOH COMPANY, LTD. (JP) 2008-03-25 US disclosed
US-7267914-B2 Electrophotographic photoconductor, process cartridge, image forming apparatus and image forming method RICOH COMPANY, LTD. (JP) 2007-09-11 US disclosed
US-20050170271-A1 Electrophotographic photoconductor, process cartridge, image forming apparatus and image forming method YAMANAMI HIROFUMI (JP) 2005-08-04 US disclosed
US-20030232265-A1 Electrophotographic photoconductor, process cartridge, image forming apparatus and image forming method RICOH COMPANY, LTD. (JP) 2003-12-18 US disclosed
EP-1324139-A2 Electrophotographic photoconductor, process cartridge, image forming apparatus and image forming method Ricoh Company, Ltd. (JP) 2003-07-02 EP disclosed