Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 13/20 | 0.69 |
| ▸ | BCHE | P06276 | 8/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.67 |
| ▸ | TP53 | P04637 | 2/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.67 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | MTOR | P42345 | 1/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.67 |
| ▸ | THPO | P40225 | 1/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30839709 | 1.00 | ACHE (0.69) | ACHEBCHEKDM4ECYP2D6TP53 | |
| SCHEMBL8321657 | 1.00 | ACHE (0.69) | ACHEBCHEKDM4ECYP2D6TP53 | |
| SCHEMBL12082976 | 1.00 | ACHE (0.69) | ACHEBCHEKDM4ECYP2D6TP53 | |
| SCHEMBL8883300 | 0.89 | ACHE (0.56) | ACHEBCHEKDM4ECYP2D6TP53 | |
| SCHEMBL9028194 | 0.89 | ACHE (0.56) | ACHEBCHEKDM4ECYP2D6TP53 | |
| SCHEMBL8669894 | 0.89 | ACHE (0.56) | ACHEBCHEKDM4ECYP2D6TP53 | |
| SCHEMBL8827788 | 0.86 | ACHE (0.67) | ACHEBCHEKDM4ECYP2D6TP53 | |
| SCHEMBL2732498 | 0.86 | ACHE (0.67) | ACHEBCHEKDM4ECYP2D6TP53 | |
| SCHEMBL9541044 | 0.86 | ACHE (0.60) | ACHEBCHEKDM4ECYP2D6TP53 | |
| SCHEMBL9541053 | 0.86 | ACHE (0.60) | ACHEBCHEKDM4ECYP2D6TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1349858-B1 | AGENTS USEFUL FOR REDUCING AMYLOID PRECURSOR PROTEIN AND TREATING DEMANTIA AND METHODS OF USE THEREOF | US GOV HEALTH & HUMAN SERV (US) | 2008-08-27 | — | — | EP | claimed |
| US-7153882-B2 | Agents useful for reducing amyloid precursor protein and treating demantia and methods of use thereof | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2006-12-26 | — | — | US | claimed |