⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6040356 | 0.90 | — | — | |
| SCHEMBL862986 | 0.74 | — | — | |
| SCHEMBL1960773 | 0.74 | — | — | |
| SCHEMBL23159616 | 0.74 | — | — | |
| SCHEMBL1489131 | 0.70 | — | — | |
| SCHEMBL502642 | 0.70 | TDP1 (0.54) | — | |
| Methane SCHEMBL28070266 | 0.69 | — | — | |
| SCHEMBL7984615 | 0.69 | — | — | |
| SCHEMBL7024466 | 0.67 | TDP1 (0.64) | — | |
| SCHEMBL7783075 | 0.67 | CA12 (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3311843-A1 | COMPOSITIONS COMPRISING DITHIOCARBAMATE AND CYCLODEXTRIN | Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts (DE) | 2018-04-25 | — | — | EP | claimed |
| US-20140220152-A1 | Compositions and Methods for Detecting, Treating, or Preventing Reductive Stress | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2014-08-07 | — | — | US | claimed |
| US-20070232692-A1 | Method of Treating Cancer Using Dithiocarbamate Derivatives | THE UNIVERSITY OF UTAH | 2007-10-04 | — | — | US | claimed |
| EP-3311843-A1 | COMPOSITIONS COMPRISING DITHIOCARBAMATE AND CYCLODEXTRIN | Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts (DE) | 2018-04-25 | — | — | EP | disclosed |
| EP-3003321-A2 | USE OF DIANHYDROGALACTITOL AND ANALOGS AND DERIVATIVES THEREOF TO TREAT RECURRENT MALIGNANT GLIOMA OR PROGRESSIVE SECONDARY BRIAN TUMOR | Del Mar Pharmaceuticals (CA) | 2016-04-13 | — | — | EP | disclosed |
| WO-2014194312-A2 | USE OF DIANHYDROGALACTITOL AND ANALOGS AND DERIVATIVES THEREOF TO TREAT RECURRENT MALIGNANT GLIOMA OR PROGRESSIVE SECONDARY BRIAN TUMOR | DEL MAR PHARMACEUTICALS (CA) | 2014-12-04 | — | — | WO | disclosed |
| US-20140220152-A1 | Compositions and Methods for Detecting, Treating, or Preventing Reductive Stress | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2014-08-07 | — | — | US | disclosed |
| US-20120030779-A1 | COMPOSITIONS AND METHODS FOR DETECTING, TREATING, OR PREVENTING REDUCTIVE STRESS | UNIVERSITY OF UTAH RESEARCH FOUNDTION (UT) | 2012-02-02 | — | — | US | disclosed |
| US-20110206756-A1 | DITHIOCARBAMATE METAL CHELATES AND METHODS OF MAKING AND USING THEREOF | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2011-08-25 | — | — | US | disclosed |
| CN-102026625-A | Dithiocarbamate metal chelates and methods of making and using thereof | UNIV UTAH RES FOUND | 2011-04-20 | — | — | CN | disclosed |
| EP-2265256-A1 | DITHIOCARBAMATE METAL CHELATES AND METHODS OF MAKING AND USING THEREOF | University of Utah Research Foundation (US) | 2010-12-29 | — | — | EP | disclosed |
| EP-1328267-A2 | METHOD OF TREATING CANCER USING DITHIOCARBAMATE DERIVATIVES | Charlotte-Mecklenburg Hospital Authority doing business as Carolinas Medical Center (US) | 2003-07-23 | — | — | EP | disclosed |
| US-6589987-B2 | Dithiocarbamate, particularly tetraethylthiuram disulfide strongly inhibits the growth of cancer cells of a variety of cell types. Such inhibitory effect is enhanced by heavy metal ions such as copper ions, cytokines and ceruloplasmin and | CHARLOTTE-MECKLENBURG HOSPITAL AUTHORITY | 2003-07-08 | — | — | US | disclosed |
| US-6548540-B2 | Administering dithiocarbamate thiolate anions to sensitize humans to conventional chemotherapy by blocking the p-glycoprotein membrane toxin extrusion pump | CHARLOTTE-MECKLENBURG HOSPITAL AUTHORITY | 2003-04-15 | — | — | US | disclosed |
| US-20030065026-A1 | METHOD OF TREATING CANCER USING TETRAETHYL THIURAM DISULFIDE | UNIVERSITY OF UTAH RESEARCH FOUNDATION | 2003-04-03 | — | — | US | disclosed |
| EP-1214063-A1 | METHOD OF TREATING CANCER USING TETRAETHYL THIURAM DISULFIDE | Charlotte-Mecklenburg Hospital Authority doing business as Carolinas Medical Center (US) | 2002-06-19 | — | — | EP | disclosed |
| WO-2002028349-A2 | METHOD OF TREATING CANCER USING DITHIOCARBAMATE DERIVATIVES | CHARLOTTE-MECKLENBURG HOSPITAL AUTHORITY, DOING BUSINESS AS CAROLINAS MEDICAL CENTER (US) | 2002-04-11 | — | — | WO | disclosed |
| US-20010016600-A1 | Method of treating cancer using dithiocarbamate derivatives | THE UNIVERSITY OF UTAH | 2001-08-23 | — | — | US | disclosed |
| WO-2001017522-A1 | METHOD OF TREATING CANCER USING TETRAETHYL THIURAM DISULFIDE | CHARLOTTE-MECKLENBURG HOSPITAL AUTHORITY DOING BUSINESS AS CAROLINAS MEDICAL CENTER (US) | 2001-03-15 | — | — | WO | disclosed |
| WO-1991005571-A1 | METHOD FOR PRODUCING BONE MARROW GROWTH CELL FACTORS | UNIVERSITY OF ROCHESTER (US) | 1991-05-02 | — | — | WO | disclosed |