⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL502641 | 0.90 | — | — | |
| SCHEMBL7783075 | 0.73 | CA12 (0.55) | — | |
| SCHEMBL8391861 | 0.71 | EPHX1 (0.47) | — | |
| SCHEMBL8391864 | 0.71 | TDP1 (0.48) | — | |
| SCHEMBL4457284 | 0.71 | EPHX1 (0.50) | — | |
| SCHEMBL7021367 | 0.70 | EPHX1 (0.63) | — | |
| SCHEMBL1678387 | 0.70 | ADH1B (0.55) | — | |
| SCHEMBL11429650 | 0.70 | EPHX1 (0.45) | — | |
| SCHEMBL8394528 | 0.70 | EPHX1 (0.50) | — | |
| SCHEMBL5319986 | 0.70 | EPHX1 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230133044-A1 | THERAPEUTIC BENEFIT OF SUBOPTIMALLY ADMINISTERED CHEMICAL COMPOUNDS | BROWN DENNIS M (US) | 2023-05-04 | — | — | US | disclosed |
| CN-115414480-A | Dianhydrogalactitol in combination with radiation for treatment of non-small cell lung cancer and glioblastoma multiforme | 德玛医药 | 2022-12-02 | — | — | CN | disclosed |
| CN-106659765-B | Use of dianhydrogalactitol and analogs or derivatives thereof for treating non-small cell lung cancer and ovarian cancer | 德玛医药 | 2021-08-13 | — | — | CN | disclosed |
| US-20190183843-A9 | USE OF DIANHYDROGALACTITOL OR DERIVATIVES OR ANALOGS THEREOF FOR TREATMENT OF PEDIATRIC CENTRAL NERVOUS SYSTEM MALIGNANCIES | DELMAR PHARMACEUTICALS, INC. (CA) | 2019-06-20 | — | — | US | disclosed |
| US-20180071244-A1 | USE OF DIANHYDROGALACTITOL OR DERIVATIVES OR ANALOGS THEREOF FOR TREATMENT OF PEDIATRIC CENTRAL NERVOUS SYSTEM MALIGNANCIES | DELMAR PHARMACEUTICALS INC (CA) | 2018-03-15 | — | — | US | disclosed |
| US-20160045502-A1 | THERAPEUTIC BENEFIT OF SUBOPTIMALLY ADMINISTERED CHEMICAL COMPOUNDS | BROWN DENNIS M (US) | 2016-02-18 | — | — | US | disclosed |
| US-7071158-B2 | Antioxidant enhancement of therapy for hyperproliferative conditions | ATHEROGENICS, INC. (US) | 2006-07-04 | — | — | US | disclosed |
| US-20010049349-A1 | Antioxidant enhancement of therapy for hyperproliferative conditions | CRABTREE ACQUISITION CO, LLC | 2001-12-06 | — | — | US | disclosed |
| EP-0433393-B1 | TREATMENT OF DAMAGED BONE MARROW AND DOSAGE UNITS THEREFOR | UNIV ROCHESTER (US) | 1995-03-15 | — | — | EP | disclosed |
| EP-0433393-A4 | TREATMENT OF DAMAGED BONE MARROW AND DOSAGE UNITS THEREFOR | — | 1992-01-15 | — | — | EP | disclosed |
| US-5035878-A | Reversing bone marrow damage resulting from chemotherapy | UNIVERSITY OF ROCHESTER (US) | 1991-07-30 | — | — | US | disclosed |
| EP-0433393-A1 | TREATMENT OF DAMAGED BONE MARROW AND DOSAGE UNITS THEREFOR. | UNIV ROCHESTER (US) | 1991-06-26 | — | — | EP | disclosed |
| US-4938949-A | Combatting side effects of anticancer drugs with dithiocarbamates | UNIVERSITY OF NEW YORK (US) | 1990-07-03 | — | — | US | disclosed |
| WO-1990002550-A1 | TREATMENT OF DAMAGED BONE MARROW AND DOSAGE UNITS THEREFOR | UNIVERSITY OF ROCHESTER (US) | 1990-03-22 | — | — | WO | disclosed |
| US-4594238-A | Administering platinum compound; then platimun binding compound | REGENTS OF UNIVERSITY OF MINNESOTA (US) | 1986-06-10 | — | — | US | disclosed |
| US-4581224-A | ANTITUMOR, ANTRICARCINOGENIC AGENTS | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 1986-04-08 | — | — | US | disclosed |