Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 2/20 | 0.68 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.68 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.68 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.68 |
| ▸ | MAP4K4 | O95819 | 9/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 4-Aminoquinazoline SCHEMBL29481714 | 1.00 | PI4KA (0.68) | PI4KAPI4K2BPI4K2API4KBMAP4K4 | |
| 4-Aminoquinazoline SCHEMBL28258394 | 0.86 | PI4KA (0.78) | PI4KAPI4K2BPI4K2API4KBMAP4K4 | |
| 4-Aminoquinazoline SCHEMBL28258393 | 0.86 | PI4KA (0.78) | PI4KAPI4K2BPI4K2API4KBMAP4K4 | |
| 4-Aminoquinazoline SCHEMBL27977310 | 0.84 | PI4KA (0.81) | PI4KAPI4K2BPI4K2API4KBMAP4K4 | |
| 4-Aminoquinazoline SCHEMBL28181385 | 0.84 | PI4KA (0.95) | PI4KAPI4K2BPI4K2API4KBMAP4K4 | |
| 4-Aminoquinazoline SCHEMBL142513 | 0.82 | PI4KA (1.00) | PI4KAPI4K2BPI4K2API4KBMAP4K4 | |
| 4-Aminoquinazoline SCHEMBL31377585 | 0.82 | PI4KA (1.00) | PI4KAPI4K2BPI4K2API4KBMAP4K4 | |
| 4-Aminoquinazoline SCHEMBL29363315 | 0.82 | PI4KA (1.00) | PI4KAPI4K2BPI4K2API4KBMAP4K4 | |
| 4-Aminoquinazoline SCHEMBL28259933 | 0.82 | PI4KA (0.70) | PI4KAPI4K2BPI4K2API4KBMAP4K4 | |
| Trifluoroacetic Acid SCHEMBL28853097 | 0.81 | MAP4K4 (0.52) | MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957462-A2 | NOVEL 2-AMINO-HETEROCYCLES UDEFUL IN THE TREATMENT OF ABETA-RELATED PATHOLOGIES | Astra Zeneca AB (SE) | 2008-08-20 | — | — | EP | claimed |
| WO-2007058583-A2 | NOVEL 2-AMINO-HETEROCYCLES USEFUL IN THE TREATMENT OF ABETA-RELATED PATHOLOGIES | ASTRAZENECA AB (SE) | 2007-05-24 | — | — | WO | claimed |
| CN-114269731-A | KIF18A inhibitors | 美国安进公司 | 2022-04-01 | — | — | CN | disclosed |
| CN-111763215-A | Compound with nitrogen-containing heterocyclic structure and preparation method and application thereof | 成都海博为药业有限公司 | 2020-10-13 | — | — | CN | disclosed |
| CN-1882572-A | Quinazoline derivatives as antitumor agents | ASTRAZENECA AB (SE) | 2006-12-20 | — | — | CN | disclosed |