Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL2 | P60568 | 6/20 | 0.48 |
| ▸ | P2RX7 | Q99572 | 5/20 | 0.34 |
| ▸ | EDNRB | P24530 | 2/20 | 0.33 |
| ▸ | EDNRA | P25101 | 2/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.32 |
| ▸ | CCNC | P24863 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5027336 | 1.00 | IL2 (0.48) | IL2P2RX7EDNRBEDNRAPIK3CD | |
| SCHEMBL5029759 | 0.84 | IL2 (0.48) | IL2P2RX7EDNRBEDNRAPIK3CD | |
| SCHEMBL5029757 | 0.84 | IL2 (0.48) | IL2P2RX7EDNRBEDNRAPIK3CD | |
| SCHEMBL5030761 | 0.82 | IL2 (0.49) | IL2P2RX7EDNRBEDNRAPIK3CD | |
| SCHEMBL5030758 | 0.82 | IL2 (0.49) | IL2P2RX7EDNRBEDNRAPIK3CD | |
| SCHEMBL5028468 | 0.75 | IL2 (0.54) | IL2MAPTMEN1HTTKMT2A | |
| SCHEMBL5028469 | 0.75 | IL2 (0.54) | IL2MAPTMEN1HTTKMT2A | |
| SCHEMBL5029678 | 0.74 | IL2 (0.51) | IL2EDNRBEDNRAPIK3CDPIK3CG | |
| SCHEMBL8232687 | 0.74 | IL2 (0.45) | IL2P2RX7EDNRBEDNRAPIK3CD | |
| SCHEMBL8227493 | 0.74 | IL2 (0.48) | IL2P2RX7EDNRBEDNRAPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8741960-B2 | Substituted aromatic compounds for inflammation and immune-related uses | SYNTA PHARMACEUTICALS CORP. (US) | 2014-06-03 | — | — | US | claimed |
| EP-1983971-A2 | SUBSTITUTED AROMATIC COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | Synta Pharmaceuticals Corporation (US) | 2008-10-29 | — | — | EP | claimed |
| US-20070249050-A1 | Substituted aromatic compounds for inflammation and immune-related uses | SYNTA PHARMACEUTICALS CORP. (US) | 2007-10-25 | — | — | US | claimed |
| WO-2007087441-A2 | SUBSTITUTED AROMATIC COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2007-08-02 | — | — | WO | claimed |
| US-20140242120-A1 | SUBSTITUTED AROMATIC COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2014-08-28 | — | — | US | disclosed |
| US-20140242120-A1 | SUBSTITUTED AROMATIC COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2014-08-28 | — | — | US | disclosed |
| US-20140242120-A1 | SUBSTITUTED AROMATIC COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2014-08-28 | — | — | US | disclosed |
| US-8741960-B2 | Substituted aromatic compounds for inflammation and immune-related uses | SYNTA PHARMACEUTICALS CORP. (US) | 2014-06-03 | — | — | US | disclosed |
| US-8741960-B2 | Substituted aromatic compounds for inflammation and immune-related uses | SYNTA PHARMACEUTICALS CORP. (US) | 2014-06-03 | — | — | US | disclosed |
| US-8741960-B2 | Substituted aromatic compounds for inflammation and immune-related uses | SYNTA PHARMACEUTICALS CORP. (US) | 2014-06-03 | — | — | US | disclosed |
| EP-1983971-A2 | SUBSTITUTED AROMATIC COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | Synta Pharmaceuticals Corporation (US) | 2008-10-29 | — | — | EP | disclosed |
| US-20070249050-A1 | Substituted aromatic compounds for inflammation and immune-related uses | SYNTA PHARMACEUTICALS CORP. (US) | 2007-10-25 | — | — | US | disclosed |
| US-20070249050-A1 | Substituted aromatic compounds for inflammation and immune-related uses | SYNTA PHARMACEUTICALS CORP. (US) | 2007-10-25 | — | — | US | disclosed |
| US-20070249050-A1 | Substituted aromatic compounds for inflammation and immune-related uses | SYNTA PHARMACEUTICALS CORP. (US) | 2007-10-25 | — | — | US | disclosed |
| WO-2007087441-A2 | SUBSTITUTED AROMATIC COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2007-08-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070249050-A1 | Substituted aromatic compounds for inflammation and immune-related uses | CCR1, NLRP1, NLRP3 | IL2 41/4885P2RX7 215/4885EDNRB 1617/4885 |
| US-20140242120-A1 | SUBSTITUTED AROMATIC COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | CCR1, NLRP1, NLRP3 | IL2 41/4885P2RX7 215/4885EDNRB 1617/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.