Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | EGFR | P00533 | 2/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | FADS1 | O60427 | 1/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.48 |
| ▸ | RORC | P51449 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3202901 | 0.92 | HTT (0.62) | HTTTSHREGFRAURKBSMN1; SMN2 | |
| SCHEMBL14600409 | 0.87 | MEN1 (0.66) | HTTTSHRSMN1; SMN2NPC1RAB9A | |
| SCHEMBL14600412 | 0.84 | HTT (0.60) | HTTSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL1094945 | 0.81 | CA12 (0.47) | HTTALDH1A1GAARORC | |
| SCHEMBL29448767 | 0.81 | CA12 (0.47) | HTTALDH1A1GAARORC | |
| SCHEMBL12228592 | 0.81 | AR (0.49) | HTTTSHREGFRAURKBMAPT | |
| SCHEMBL30668235 | 0.81 | CA12 (0.47) | HTTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL6814996 | 0.81 | CA12 (0.47) | HTTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL29666354 | 0.81 | AR (0.49) | HTTTSHREGFRAURKBMAPT | |
| SCHEMBL23024750 | 0.80 | MAP4K4 (0.49) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1299381-B1 | SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS | ASTRAZENECA AB (SE) | 2008-05-07 | — | — | EP | disclosed |