Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.62 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | NPC1 | O15118 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | CASP3 | P42574 | 1/20 | 0.55 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.53 |
| ▸ | RORC | P51449 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14600409 | 0.94 | MEN1 (0.66) | HTTTSHRSLC2A1MEN1KMT2A | |
| SCHEMBL5027770 | 0.92 | HTT (0.54) | HTTTSHRSLC2A1MEN1KMT2A | |
| SCHEMBL14600412 | 0.91 | HTT (0.60) | HTTSLC2A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL29666354 | 0.88 | AR (0.49) | HTTTSHRSLC2A1MAPTEGFR | |
| SCHEMBL12228592 | 0.88 | AR (0.49) | HTTTSHRSLC2A1MAPTEGFR | |
| SCHEMBL30681937 | 0.86 | HPGD (0.51) | HTTTSHRMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL941486 | 0.86 | HPGD (0.51) | HTTTSHRMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL16303890 | 0.86 | EPHX1 (0.58) | HTTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL15559868 | 0.85 | HTT (0.52) | HTTTSHRSLC2A1MEN1KMT2A | |
| SCHEMBL3930649 | 0.84 | MAPT (0.66) | HTTTSHRSLC2A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100048898-A1 | Process for Synthesizing 7-Alkynyl-4- Aminoquinazolines and a Related Intermediate | AVEO PHARMACEUTICALS, INC. | 2010-02-25 | — | — | US | claimed |
| EP-2010183-A2 | PROCESSES FOR SYNTHESIZING 7-ALKYNYL-4-AMINOQUINAZOLINES AND A RELATED INTERMEDIATE | Aveo Pharmaceuticals, Inc. (US) | 2009-01-07 | — | — | EP | claimed |
| WO-2007103233-A2 | PROCESSES FOR SYNTHESIZING 7-ALKYNYL-4-AMINOQUINAZOLINES AND A RELATED INTERMEDIATE | AVEO PHARMACEUTICALS, INC. (US) | 2007-09-13 | — | — | WO | claimed |
| WO-2024222614-A1 | HETEROCYCLIC GSPT1 DEGRADATION AGENT | 北京诺诚健华医药科技有限公司 | 2024-10-31 | — | — | WO | disclosed |
| CN-116332905-A | (S) -N-phenyl-1- (pyridin-2-yl) pyrrolidine-2-carboxamide derivatives | 上海翊石医药科技有限公司 | 2023-06-27 | — | — | CN | disclosed |
| CN-109843892-B | Oxadiazepinone derivatives and their use in the treatment of hepatitis B infections | 诺维拉治疗公司 | 2022-01-25 | — | — | CN | disclosed |
| US-20100048898-A1 | Process for Synthesizing 7-Alkynyl-4- Aminoquinazolines and a Related Intermediate | AVEO PHARMACEUTICALS, INC. | 2010-02-25 | — | — | US | disclosed |
| US-20100048898-A1 | Process for Synthesizing 7-Alkynyl-4- Aminoquinazolines and a Related Intermediate | AVEO PHARMACEUTICALS, INC. | 2010-02-25 | — | — | US | disclosed |
| US-20100048898-A1 | Process for Synthesizing 7-Alkynyl-4- Aminoquinazolines and a Related Intermediate | AVEO PHARMACEUTICALS, INC. | 2010-02-25 | — | — | US | disclosed |
| US-20100022467-A1 | ANTI-CANCER PHOSPHONATE ANALOGS | BOOJAMRA CONSTANTINE G | 2010-01-28 | — | — | US | disclosed |
| US-20090181930-A1 | KINASE INHIBITORY PHOSPHONATE ANALOGS | CANNIZZARO CARINA | 2009-07-16 | — | — | US | disclosed |
| WO-2007103233-A2 | PROCESSES FOR SYNTHESIZING 7-ALKYNYL-4-AMINOQUINAZOLINES AND A RELATED INTERMEDIATE | AVEO PHARMACEUTICALS, INC. (US) | 2007-09-13 | — | — | WO | disclosed |
| WO-2007103233-A2 | PROCESSES FOR SYNTHESIZING 7-ALKYNYL-4-AMINOQUINAZOLINES AND A RELATED INTERMEDIATE | AVEO PHARMACEUTICALS, INC. (US) | 2007-09-13 | — | — | WO | disclosed |
| CN-1267431-C | Substituted quinazoline derivatives and their use as inhibitors | ASTRAZENECA AB (SE) | 2006-08-02 | — | — | CN | disclosed |
| US-20060046987-A1 | Substituted quinazoline derivatives and their use as inhibitors | ASTRAZENECA AB (SE) | 2006-03-02 | — | — | US | disclosed |
| US-6919338-B2 | Substituted quinazoline derivatives and their use as inhibitors of aurora-2 kinase | ASTRAZENECA AB (SE) | 2005-07-19 | — | — | US | disclosed |
| CN-1496364-A | Substituted quinazoline derivatives and their use as inhibitors | — | 2004-05-12 | — | — | CN | disclosed |
| US-20030187002-A1 | Substituted quinazoline derivatives and their use as inhibitors | ASTRAZENECA AB (SE) | 2003-10-02 | — | — | US | disclosed |
| EP-1299381-A1 | SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS | AstraZeneca AB (SE) | 2003-04-09 | — | — | EP | disclosed |
| WO-2002000649-A1 | SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS | ASTRAZENECA AB (SE) | 2002-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048898-A1 | Process for Synthesizing 7-Alkynyl-4- Aminoquinazolines and a Related Intermediate | CYP3A7, UGT2B7, UGT1A7 | HTT 1043/4885TSHR 4628/4885SLC2A1 4562/4885 |
| US-20090181930-A1 | KINASE INHIBITORY PHOSPHONATE ANALOGS | PIK3CA, PNKP, PIK3CB | HTT 4357/4885TSHR 3334/4885SLC2A1 2326/4885 |
| US-20100022467-A1 | ANTI-CANCER PHOSPHONATE ANALOGS | PIK3CA, PHOSPHO1, PTEN | HTT 4035/4885TSHR 4311/4885SLC2A1 1703/4885 |
| US-20060046987-A1 | Substituted quinazoline derivatives and their use as inhibitors | AURKA, AURKB, AURKC | HTT 4307/4885TSHR 2960/4885SLC2A1 4435/4885 |
| US-20030187002-A1 | Substituted quinazoline derivatives and their use as inhibitors | AURKA, AURKC, AURKB | HTT 4535/4885TSHR 3868/4885SLC2A1 4459/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.