Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 5/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.49 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.48 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.47 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.46 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.46 |
| ▸ | DHFR | P00374 | 3/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | CHUK | O15111 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25559628 | 0.83 | PTGDR2 (0.48) | ADORA1ADORA2APTGDR2TBXA2RPTGDR | |
| SCHEMBL15156679 | 0.82 | ADORA1 (0.53) | ADORA1ADORA2AALDH1A1MAPT | |
| SCHEMBL30268103 | 0.82 | ADORA1 (0.53) | ADORA1ADORA2AALDH1A1MAPT | |
| SCHEMBL5454611 | 0.81 | ADORA1 (0.45) | ADORA1ADORA2APTGDR2ADORA2BDHFR | |
| SCHEMBL28402866 | 0.75 | DHFR (0.44) | ADORA1ADORA2ADHFRMAPTKMT2A | |
| SCHEMBL29808838 | 0.75 | DHFR (0.44) | ADORA1ADORA2ADHFRMAPTKMT2A | |
| SCHEMBL5455467 | 0.75 | ADORA1 (0.64) | ADORA1ADORA2AADORA2BDHFR | |
| SCHEMBL3820130 | 0.74 | DPP4 (0.46) | ADORA1ADORA2APTGDR2ADORA2BTBXA2R | |
| SCHEMBL5447978 | 0.73 | ADORA1 (0.69) | ADORA1ADORA2AADORA2BDHFRKMT2A | |
| SCHEMBL19344296 | 0.72 | PTGDR2 (0.46) | ADORA2APTGDR2TBXA2RPTGDRUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2450358-A1 | Fused, tricyclic sulfonamide inhibitors of gamma secretase | Elan Pharmaceuticals Inc. (US) | 2012-05-09 | — | — | EP | disclosed |