Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5028997 | 0.83 | SMN1; SMN2 (0.42) | ALDH1A1GRM5CYP2C19TSHRCYP2C9 | |
| SCHEMBL5033385 | 0.83 | KDM4E (0.44) | KCNA5ALDH1A1GRM5CYP3A4CYP2C19 | |
| SCHEMBL4631647 | 0.82 | KCNA5 (0.49) | KCNA5ALDH1A1GRM5CYP3A4CYP2C19 | |
| SCHEMBL29078127 | 0.82 | KCNA5 (0.49) | KCNA5ALDH1A1GRM5CYP3A4CYP2C19 | |
| SCHEMBL1516145 | 0.82 | ALDH1A1 (0.50) | KCNA5ALDH1A1GRM5CYP3A4CYP2C19 | |
| SCHEMBL12068487 | 0.82 | ALDH1A1 (0.50) | KCNA5ALDH1A1GRM5CYP3A4CYP2C19 | |
| SCHEMBL5027031 | 0.81 | KCNA5 (0.50) | KCNA5ALDH1A1CYP3A4CYP2C19TSHR | |
| SCHEMBL14777447 | 0.81 | KCNA5 (0.47) | KCNA5ALDH1A1GRM5CYP3A4CYP2C19 | |
| Hydrochloric Acid SCHEMBL68317 | 0.81 | ALDH1A1 (0.53) | KCNA5ALDH1A1GRM5CYP3A4CYP2C19 | |
| SCHEMBL4611680 | 0.78 | KCNA5 (0.45) | KCNA5ALDH1A1GRM5CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007393-A2 | THIAZOLE AND THIOPHENE ANALOGUES, AND THEIR USE IN TREATING AUTOIMMUNE DISEASES AND CANCERS | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College (US) | 2008-12-31 | — | — | EP | disclosed |
| WO-2007118149-A2 | THIAZOLE AND THIOPHENE ANALOGUES, AND THEIR USE IN TREATING AUTOIMMUNE DISEASES AND CANCERS | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL LOLLEGE (US) | 2007-10-18 | — | — | WO | disclosed |