Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GALR1 | P47211 | 4/20 | 0.58 |
| ▸ | DRD2 | P14416 | 6/20 | 0.45 |
| ▸ | GALR2 | O43603 | 3/20 | 0.43 |
| ▸ | MAP3K8 | P41279 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4832720 | 0.99 | GALR1 (0.59) | GALR1DRD2GALR2 | |
| SCHEMBL4829406 | 0.99 | GALR1 (0.59) | GALR1DRD2GALR2 | |
| SCHEMBL4832076 | 0.99 | GALR1 (0.59) | GALR1DRD2GALR2 | |
| SCHEMBL5036362 | 0.99 | GALR1 (0.59) | GALR1DRD2GALR2 | |
| Hydrochloric Acid SCHEMBL5029234 | 0.98 | GALR1 (0.58) | GALR1DRD2GALR2 | |
| SCHEMBL5029158 | 0.98 | GALR1 (0.57) | GALR1DRD2GALR2 | |
| SCHEMBL5031252 | 0.97 | GALR1 (0.59) | GALR1DRD2GALR2 | |
| SCHEMBL5031357 | 0.95 | GALR1 (0.54) | GALR1DRD2GALR2 | |
| SCHEMBL4829744 | 0.94 | DRD2 (0.50) | GALR1DRD2GALR2 | |
| SCHEMBL4832495 | 0.94 | DRD2 (0.50) | GALR1DRD2GALR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7332488-B2 | Methods and compositions of novel triazine compounds | REDDY US THERAPEUTICS, INC. (US) | 2008-02-19 | — | — | US | disclosed |