Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 6/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 6/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | EGFR | P00533 | 2/20 | 0.53 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.53 |
| ▸ | KMO | O15229 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | BCR | P11274 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16840691 | 0.84 | HRH4 (0.55) | PIK3CBNPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL5144566 | 0.84 | NUDT1 (0.56) | PIK3CBNPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL1597538 | 0.83 | PIK3CB (0.58) | PIK3CBCYP2C19NPC1ALDH1A1ATM | |
| SCHEMBL31110333 | 0.82 | CYP2C19 (0.68) | PIK3CBCYP2C19NPC1ALDH1A1ATM | |
| SCHEMBL28051953 | 0.81 | NPC1 (0.56) | PIK3CBCYP2C19NPC1ALDH1A1ATM | |
| SCHEMBL17623265 | 0.80 | HRH4 (0.63) | CYP2C19ALDH1A1AKT1 | |
| SCHEMBL19027129 | 0.80 | NPC1 (0.58) | PIK3CBCYP2C19NPC1ALDH1A1ATM | |
| SCHEMBL564532 | 0.78 | PIK3CB (0.56) | PIK3CBCYP2C19NPC1ALDH1A1ATM | |
| SCHEMBL10272311 | 0.77 | CYP2C19 (0.63) | PIK3CBCYP2C19NPC1ALDH1A1ATM | |
| SCHEMBL5031512 | 0.77 | PIK3CB (0.62) | PIK3CBCYP2C19NPC1ALDH1A1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015091584-A1 | THIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND THEIR USE AS TYK2 KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2015-06-25 | — | — | WO | disclosed |
| CN-101438288-A | Regulation of phosphoryl transferase activity of glutamine synthetase | CSIR CORP (ZA) | 2009-05-20 | — | — | CN | disclosed |
| EP-2008210-A1 | MODULATION OF PHOSPHORYL TRANSFERASE ACTIVITY OF GLUTAMINE SYNTHETASE | CSIR (ZA) | 2008-12-31 | — | — | EP | disclosed |
| WO-2007105023-A1 | MODULATION OF PHOSPHORYL TRANSFERASE ACTIVITY OF GLUTAMINE SYNTHETASE | CSIR (ZA) | 2007-09-20 | — | — | WO | disclosed |
| WO-2007105023-A1 | MODULATION OF PHOSPHORYL TRANSFERASE ACTIVITY OF GLUTAMINE SYNTHETASE | CSIR (ZA) | 2007-09-20 | — | — | WO | disclosed |