Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 1/20 | 0.50 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5030262 | 0.94 | DDB1 (0.48) | DDB1CRBNALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL16661304 | 0.88 | DDB1 (0.56) | DDB1CRBNALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL18493339 | 0.85 | DDB1 (0.54) | DDB1CRBNALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL7228727 | 0.83 | DDB1 (0.52) | DDB1CRBNALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL1200111 | 0.81 | DDB1 (0.54) | DDB1CRBNALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL25317301 | 0.81 | ALDH1A1 (0.51) | DDB1CRBNALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL25787780 | 0.81 | DDB1 (0.57) | DDB1CRBNALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL5358863 | 0.81 | KMT2A (0.54) | DDB1CRBNALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL16104359 | 0.81 | DDB1 (0.54) | DDB1CRBNALDH1A1MAPK1L3MBTL1 | |
| Fluoride SCHEMBL27773141 | 0.79 | ALDH1A1 (0.50) | DDB1CRBNALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981888-A2 | INHIBITORS OF TYROSINE KINASES AND USES THEREOF | Pharmacyclics, Inc. (US) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007087068-A2 | INHIBITORS OF TYROSINE KINASES AND USES THEREOF | PHARMACYCLICS, INC. (US) | 2007-08-02 | — | — | WO | disclosed |