Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | CNR2 | P34972 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | AGER | Q15109 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5036963 | 0.97 | TNF (0.56) | TNFHDAC1CNR2ALDH1A1TSHR | |
| SCHEMBL7428949 | 0.84 | TNF (0.56) | TNFHDAC1CNR2ALDH1A1TSHR | |
| SCHEMBL7430629 | 0.82 | TNF (0.54) | TNFHDAC1CNR2ALDH1A1TSHR | |
| SCHEMBL5034642 | 0.81 | AAK1 (0.53) | TNFHDAC1CNR2ALDH1A1TSHR | |
| SCHEMBL5036942 | 0.81 | TNF (0.53) | TNFHDAC1CNR2ALDH1A1TSHR | |
| SCHEMBL5033744 | 0.77 | MMP2 (0.46) | TNFHDAC1ALDH1A1KDM4EHTT | |
| SCHEMBL5033746 | 0.77 | MMP2 (0.46) | TNFHDAC1ALDH1A1KDM4EHTT | |
| SCHEMBL2860549 | 0.76 | TNF (0.55) | TNFHDAC1CNR2ALDH1A1TSHR | |
| SCHEMBL27767304 | 0.73 | APEX1 (0.47) | CNR2ALDH1A1KDM4E | |
| SCHEMBL5036965 | 0.72 | TNF (0.47) | TNFHDAC1CNR2ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1918278-A1 | Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases | Novartis AG (CH) | 2008-05-07 | — | — | EP | disclosed |
| US-6410580-B1 | ANTIINFLAMMATORY AGENTS, RHEUMATIC DISEASES | NOVARTIS AG (CH) | 2002-06-25 | — | — | US | disclosed |
| US-6277987-B1 | FOR INHIBITING MATRIX-DEGRADING METALLOPROTEINASES IN MAMMALS | NOVARTIS AG (CH) | 2001-08-21 | — | — | US | disclosed |