Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.41 |
| ▸ | KIF11 | P52732 | 2/20 | 0.39 |
| ▸ | TYR | P14679 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MLKL | Q8NB16 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4246459 | 0.87 | KDM4E (0.53) | HSD17B10KDM4ELMNACYP2A6KIF11 | |
| SCHEMBL23676474 | 0.85 | HSD17B10 (0.54) | HSD17B10KDM4ELMNAALDH1A1HPGD | |
| SCHEMBL23676475 | 0.81 | HSD17B10 (0.50) | HSD17B10KDM4ELMNAALDH1A1HPGD | |
| SCHEMBL6985209 | 0.80 | KDM4E (0.42) | HSD17B10KDM4ELMNAKIF11TYR | |
| SCHEMBL4241831 | 0.79 | BRD4 (0.35) | HSD17B10KDM4ELMNACYP2A6KIF11 | |
| SCHEMBL889055 | 0.78 | CYP2A6 (0.44) | HSD17B10KDM4ECYP2A6KIF11BRD4 | |
| SCHEMBL4246422 | 0.77 | MAPT (0.50) | KDM4ELMNACYP2A6KIF11BRD4 | |
| SCHEMBL2757079 | 0.76 | KDM4E (0.59) | HSD17B10KDM4ELMNAALDH1A1HPGD | |
| SCHEMBL12032930 | 0.76 | HSD17B10 (0.64) | HSD17B10KDM4ELMNAALDH1A1HPGD | |
| SCHEMBL889358 | 0.76 | HSD17B10 (0.59) | HSD17B10KDM4ELMNAKIF11ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1993536-A2 | THIAZOLONES FOR USE AS PI3 KINASE INHIBITORS | SmithKline Beecham Corporation (US) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007103755-A2 | THIAZOLONES FOR USE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-09-13 | — | — | WO | disclosed |