Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.41 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 10/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31378991 | 0.81 | PNMT (0.41) | PNMTCES2TACR1 | |
| SCHEMBL15211541 | 0.81 | PNMT (0.41) | PNMTPDE2ACES2TACR1IDO1 | |
| SCHEMBL5610427 | 0.79 | PDE2A (0.51) | PNMTPDE2ACES2TACR1IDO1 | |
| SCHEMBL2394599 | 0.79 | PDE2A (0.51) | PNMTPDE2ACES2TACR1IDO1 | |
| SCHEMBL25920947 | 0.78 | PNMT (0.47) | PNMTPDE2ACES2TACR1IDO1 | |
| SCHEMBL6484095 | 0.76 | PNMT (0.46) | PNMTPDE2ACES2TACR1IDO1 | |
| SCHEMBL459815 | 0.76 | PNMT (0.46) | PNMTPDE2ACES2TACR1IDO1 | |
| SCHEMBL264592 | 0.76 | PNMT (0.46) | PNMTPDE2ACES2TACR1IDO1 | |
| SCHEMBL9903281 | 0.76 | PNMT (0.42) | PNMTPDE2ACES2TACR1 | |
| SCHEMBL17243750 | 0.75 | PNMT (0.36) | PNMTPDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1973546-B1 | CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS | MERCK SHARP & DOHME (US) | 2012-06-13 | — | — | EP | disclosed |
| EP-1973546-A2 | CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS | Merck & Co., Inc. (US) | 2008-10-01 | — | — | EP | disclosed |
| WO-2007081570-A2 | CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS | MERCK & CO., INC. (US) | 2007-07-19 | — | — | WO | disclosed |