SCHEMBL503236

SCHEMBL503236

C#Cc1ccc(C)nc1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL1358000 0.98 CYP1A2 (0.53)
SCHEMBL29794327 0.76
SCHEMBL171975 0.76
SCHEMBL1042079 0.76
SCHEMBL30626044 0.75 HDAC8 (0.40)
SCHEMBL27733 0.75 HDAC8 (0.40)
Hydrochloric Acid SCHEMBL8845303 0.74 ALDH1A1 (0.53)
SCHEMBL9290564 0.74 CYP1A2 (0.58)
Hydrochloric Acid SCHEMBL4432024 0.74 ALDH1A1 (0.53)
SCHEMBL24435938 0.73 GRM5 (0.51)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 304 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102731374-B Improved process for preparing 1-(6-methylpyridin-3-yl)-2-[4-(methylsulfonyl)phenyl]ethanone, an intermediate of etoricoxib ITALIANA SINT SPA 2015-05-06 CN claimed
US-8664402-B2 Process for preparing 1-(6-methylpyridin-3-yl)-2-[4-(methylsulfonyl)phenyl]ethanone, an intermediate of etoricoxib F.I.S. FABBRICA ITALIANA SINTETICI S.P.A. (IT) 2014-03-04 US claimed
EP-2497767-B1 Improved process for preparing 1-(6-methylpyridin-3-yl)-2-[4-(methylsulfonyl)phenyl]ethanone, an intermediate of etoricoxib ITALIANA SINT SPA (IT) 2013-05-29 EP claimed
CN-102731374-A Improved process for preparing 1-(6-methylpyridin-3-yl)-2-[4-(methylsulfonyl)phenyl]ethanone, an intermediate of etoricoxib ITALIANA SINT SPA 2012-10-17 CN claimed
US-20120232281-A1 PROCESS FOR PREPARING 1-(6-METHYLPYRIDIN-3-YL)-2-[4-(METHYLSULFONYL)PHENYL]ETHANONE, AN INTERMEDIATE OF ETORICOXIB F.I.S. FABBRICA ITALIANA SINTETICI S.P.A. (IT) 2012-09-13 US claimed
EP-2497767-A1 Improved process for preparing 1-(6-methylpyridin-3-yl)-2-[4-(methylsulfonyl)phenyl]ethanone, an intermediate of etoricoxib F.I.S. Fabbrica Italiana Sintetici S.p.A. (IT) 2012-09-12 EP claimed
US-20260108870-A1 POLYMER ADSORBENTS FOR SELECTIVE IONS ADSORPTION UNIV NANYANG TECH (SG) 2026-04-23 US disclosed
US-20250257076-A1 SUBSTITUTED PYRROLIDINE-2-CARBOXYLIC ACID DERIVATIVES AS cGAS INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2025-08-14 US disclosed
US-20250250269-A1 HETEROCYCLIC GLP-1 AGONISTS GASHERBRUM BIO, INC. 2025-08-07 US disclosed
US-20250145596-A1 HETEROCYCLIC GLP-1 AGONISTS GASHERBRUM BIO, INC. 2025-05-08 US disclosed
EP-4522667-A2 POLYMER ADSORBENTS FOR SELECTIVE IONS ADSORPTION Nanyang Technological University (SG) 2025-03-19 EP disclosed
EP-4508047-A1 HETEROCYCLIC GLP-1 AGONISTS Gasherbrum Bio, Inc. (US) 2025-02-19 EP disclosed
CN-119255988-A Heterocyclic GLP-1 agonists 加舒布鲁姆生物公司 2025-01-03 CN disclosed
US-5629325-A TREATMENT OF NERVOUS SYSTEM DISORDERS; NEURONAL NICOTINIC CHOLINERGIC COMPOUNDS ABBOTT LABORATORIES (US) 1997-05-13 US disclosed
US-4871868-A FROM AN ORGANIC HALIDE OR AN ARYL SULFONATE AND AN ALKALI METAL ACETYLIDE, 1,3-DIALKYL-2-IMIDAZOLIDINONE PROMOTER TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1989-10-03 US disclosed
EP-0284237-A1 Production of substituted acetylenic compounds Takeda Chemical Industries, Ltd. (JP) 1988-09-28 EP disclosed
US-4457934-A ESTER DERIVATIVE OF PYRIDINE STAUFFER CHEMICAL COMPANY (US) 1984-07-03 US disclosed
EP-0001887-B1 IMIDAZO(1,2-A)PYRIDINE COMPOUNDS, THEIR PREPARATION AND ANTHELMINTIC COMPOSITIONS CONTAINING THEM MERCK & CO. INC. (US) 1981-10-21 EP disclosed
EP-0001887-A1 Imidazo(1,2-a)pyridine compounds, their preparation and anthelmintic compositions containing them MERCK & CO. INC. (US) 1979-05-16 EP disclosed
US-4154835-A Anthelmintic imidazo [1,2-a] pyridines MERCK & CO., INC. (US) 1979-05-15 US disclosed