Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 13/20 | 0.35 |
| ▸ | CX3CR1 | P49238 | 9/20 | 0.34 |
| ▸ | HTR1B | P28222 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12022718 | 0.55 | CXCR2 (0.71) | CXCR2CX3CR1HTR1B | |
| SCHEMBL213575 | 0.55 | CXCR2 (0.62) | CXCR2CX3CR1HTR1B | |
| SCHEMBL8663220 | 0.53 | RPS6KA3 (0.32) | — | |
| SCHEMBL8124140 | 0.53 | — | — | |
| SCHEMBL17904270 | 0.48 | RPS6KA3 (0.37) | CXCR2 | |
| SCHEMBL12281708 | 0.46 | — | — | |
| SCHEMBL9732756 | 0.44 | LMNA (0.46) | — | |
| SCHEMBL8664696 | 0.41 | LIMK1 (0.39) | — | |
| SCHEMBL23214568 | 0.40 | — | — | |
| SCHEMBL21720492 | 0.40 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1348709-B1 | Thiazolo[4,5-d]pyrimidine compounds for the treatment of rheumatoid arthritis | ASTRAZENECA UK LTD (GB) | 2008-01-16 | — | — | EP | disclosed |