Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP3 | P08254 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | AKT1 | P31749 | 1/20 | 0.45 |
| ▸ | CTSK | P43235 | 5/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2640680 | 0.91 | ALDH1A1 (0.51) | MMP2MMP3MMP9MMP13AKT1 | |
| SCHEMBL31649378 | 0.91 | ALDH1A1 (0.51) | MMP2MMP3MMP9MMP13AKT1 | |
| SCHEMBL2640679 | 0.91 | ALDH1A1 (0.51) | MMP2MMP3MMP9MMP13AKT1 | |
| SCHEMBL31649040 | 0.87 | ALDH1A1 (0.52) | MMP2MMP3MMP9MMP13AKT1 | |
| SCHEMBL25322940 | 0.86 | NPC1 (0.46) | MMP2MMP3MMP9MMP13AKT1 | |
| SCHEMBL25322938 | 0.86 | NPC1 (0.46) | MMP2MMP3MMP9MMP13AKT1 | |
| SCHEMBL30550754 | 0.86 | NPC1 (0.46) | MMP2MMP3MMP9MMP13AKT1 | |
| SCHEMBL6388649 | 0.85 | AKT1 (0.46) | AKT1CTSKIDO1ALDH1A1CTSS | |
| SCHEMBL34475725 | 0.84 | NPC1 (0.44) | MMP2MMP3MMP9MMP13AKT1 | |
| SCHEMBL31649054 | 0.83 | AKT1 (0.49) | MMP2MMP3MMP9MMP13AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1918278-A1 | Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases | Novartis AG (CH) | 2008-05-07 | — | — | EP | disclosed |
| US-6410580-B1 | ANTIINFLAMMATORY AGENTS, RHEUMATIC DISEASES | NOVARTIS AG (CH) | 2002-06-25 | — | — | US | disclosed |
| US-6277987-B1 | FOR INHIBITING MATRIX-DEGRADING METALLOPROTEINASES IN MAMMALS | NOVARTIS AG (CH) | 2001-08-21 | — | — | US | disclosed |