Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | PLG | P00747 | 1/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.47 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.47 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.46 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28025742 | 0.98 | PBRM1 (0.53) | PBRM1NPSR1SMN1; SMN2HSD17B10NPC1 | |
| SCHEMBL6061451 | 0.85 | ATM (0.46) | NPSR1NPC1LMNAPOLBF2 | |
| SCHEMBL8003710 | 0.83 | PBRM1 (0.59) | PBRM1NPSR1SMN1; SMN2HSD17B10NPC1 | |
| SCHEMBL9510637 | 0.82 | PBRM1 (0.57) | PBRM1NPSR1SMN1; SMN2HSD17B10NPC1 | |
| SCHEMBL999693 | 0.82 | PBRM1 (0.57) | PBRM1NPSR1SMN1; SMN2HSD17B10NPC1 | |
| SCHEMBL29071827 | 0.80 | PBRM1 (0.55) | PBRM1NPSR1SMN1; SMN2HSD17B10NPC1 | |
| SCHEMBL13399668 | 0.80 | PBRM1 (0.55) | PBRM1NPSR1SMN1; SMN2HSD17B10NPC1 | |
| SCHEMBL28539853 | 0.80 | PBRM1 (0.55) | PBRM1NPSR1SMN1; SMN2HSD17B10NPC1 | |
| SCHEMBL27515709 | 0.80 | PARP1 (0.57) | HSD17B10POLBALDH1A1CYP3A4RECQL | |
| SCHEMBL28045479 | 0.80 | PBRM1 (0.55) | PBRM1NPSR1SMN1; SMN2HSD17B10NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1906958-A2 | PYRAZOLO[3,4-B]PYRIDIN-2-YL]-BENZOIC ACID DERIVATIVES AS HIV INTEGRASE INHIBITORS | Ambrilia Biopharma Inc. (CA) | 2008-04-09 | — | — | EP | disclosed |
| WO-2007000043-A2 | PYRAZOLO[3,4-B]PYRIDIN-2-YL]-BENZOIC ACID DERIVATIVES AS HIV INTEGRASE INHIBITORS | AMBRILIA BIOPHARMA INC. (CA) | 2007-01-04 | — | — | WO | disclosed |