Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 6/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | TNF | P01375 | 1/20 | 0.42 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.42 |
| ▸ | PIP4K2A | P48426 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.41 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1922893 | 0.81 | GPR119 (0.55) | IRAK4HTTSMN1; SMN2MALT1RAB9A | |
| SCHEMBL16406300 | 0.78 | IRAK4 (1.00) | IRAK4HTTSMN1; SMN2MALT1 | |
| SCHEMBL1605139 | 0.77 | HTT (1.00) | IRAK4HTTSMN1; SMN2RAB9AMAPT | |
| SCHEMBL27378075 | 0.75 | IRAK4 (0.65) | IRAK4HTTSMN1; SMN2MALT1RAB9A | |
| SCHEMBL5037731 | 0.75 | MEN1 (0.55) | MEN1KMT2A | |
| SCHEMBL1604201 | 0.75 | HTT (0.75) | IRAK4HTTSMN1; SMN2MALT1RAB9A | |
| SCHEMBL1604038 | 0.73 | HTT (0.52) | IRAK4HTTSMN1; SMN2MALT1RAB9A | |
| SCHEMBL6640537 | 0.73 | IRAK4 (0.59) | IRAK4HTTSMN1; SMN2MALT1RAB9A | |
| SCHEMBL12710367 | 0.72 | HTT (0.77) | IRAK4HTTSMN1; SMN2RAB9AMEN1 | |
| SCHEMBL18538841 | 0.72 | IRAK4 (0.60) | IRAK4HTTSMN1; SMN2MALT1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1622914-A4 | NEW PIPERIDINYLAMINO-THIENO 2,3-D PYRIMIDINE COMPOUNDS | EPIX DELAWARE INC (US) | 2008-03-12 | — | — | EP | disclosed |
| EP-1622914-A2 | NEW PIPERIDINYLAMINO-THIENO 2,3-D PYRIMIDINE COMPOUNDS | Predix Pharmaceuticals Holdings, Inc. (US) | 2006-02-08 | — | — | EP | disclosed |
| WO-2004089312-A2 | NEW PIPERIDINYLAMINO-THIENO[2,3-D] PYRIMIDINE COMPOUNDS | PREDIX PHARMACEUTICALS HOLDINGS, INC. (US) | 2004-10-21 | — | — | WO | disclosed |