Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 6/20 | 0.35 |
| ▸ | KDM1B | Q8NB78 | 4/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26762111 | 0.82 | KDM1A (0.33) | KDM1AKDM1BKCNH2 | |
| SCHEMBL4543473 | 0.80 | ADRB2 (0.34) | KDM1AKDM1BKCNH2 | |
| SCHEMBL246565 | 0.80 | ADRB2 (0.34) | KDM1AKDM1BKCNH2 | |
| SCHEMBL4540179 | 0.80 | ADRB2 (0.34) | KDM1AKDM1BKCNH2 | |
| SCHEMBL247386 | 0.79 | KDM1A (0.31) | KDM1AKDM1B | |
| SCHEMBL247086 | 0.77 | CYP1A2 (0.33) | KDM1AKDM1B | |
| SCHEMBL13836037 | 0.76 | ADRB2 (0.32) | — | |
| SCHEMBL13836040 | 0.76 | ADRB2 (0.32) | — | |
| SCHEMBL1420901 | 0.76 | ADRB2 (0.32) | — | |
| SCHEMBL3181616 | 0.76 | ADRB2 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012062751-A1 | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | Janssen Pharmaceuticals, Inc. (US) | 2012-05-18 | — | — | WO | disclosed |