Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.60 |
| ▸ | PREP | P48147 | 2/20 | 0.52 |
| ▸ | DPP4 | P27487 | 1/20 | 0.52 |
| ▸ | FAP | Q12884 | 1/20 | 0.52 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.52 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29676812 | 1.00 | KDM4E (0.60) | KDM4EALOX15TSHRSIRT1PREP | |
| SCHEMBL23230044 | 0.85 | KDM4E (0.55) | KDM4EALOX15TSHRSIRT1PREP | |
| SCHEMBL29676908 | 0.85 | KDM4E (0.71) | KDM4EALOX15TSHRSIRT1PREP | |
| SCHEMBL311850 | 0.85 | KDM4E (0.71) | KDM4EALOX15TSHRSIRT1PREP | |
| SCHEMBL3785757 | 0.84 | KDM4E (0.75) | KDM4EALOX15TSHRSIRT1SMN1; SMN2 | |
| SCHEMBL15233574 | 0.83 | KDM4E (0.60) | KDM4EALOX15TSHRSIRT1PREP | |
| SCHEMBL25130172 | 0.83 | KDM4E (0.60) | KDM4EALOX15TSHRSIRT1PREP | |
| SCHEMBL29676768 | 0.83 | THRB (0.58) | KDM4EALOX15TSHRSIRT1PREP | |
| SCHEMBL7997184 | 0.83 | KDM4E (0.68) | KDM4EALOX15TSHRSIRT1DPP4 | |
| SCHEMBL11001425 | 0.83 | KDM4E (0.52) | KDM4EALOX15TSHRSIRT1PREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1450796-B1 | BENZOTHIAZOLE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2008-04-09 | — | — | EP | disclosed |
| US-6596718-B1 | A compound of formula I has a good affinity to the A2A receptor and is useful for the treatment of diseases mediated by this receptor. | HOFFMANN-LA ROCHE INC. | 2003-07-22 | — | — | US | disclosed |