Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 7/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.39 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.36 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5034665 | 1.00 | KDR (0.42) | KDRTRPV1MEN1GAACASP1 | |
| SCHEMBL3586822 | 0.90 | TRPV1 (0.39) | KDRTRPV1MEN1KMT2ANPC1 | |
| SCHEMBL3586815 | 0.90 | TRPV1 (0.39) | KDRTRPV1MEN1KMT2ANPC1 | |
| SCHEMBL3590891 | 0.89 | TRPV1 (0.43) | KDRTRPV1NPC1RAB9A | |
| SCHEMBL3590895 | 0.89 | TRPV1 (0.43) | KDRTRPV1NPC1RAB9A | |
| SCHEMBL3592868 | 0.85 | KDR (0.56) | KDRTRPV1MEN1GAACASP1 | |
| SCHEMBL3592870 | 0.85 | KDR (0.56) | KDRTRPV1MEN1GAACASP1 | |
| SCHEMBL13544332 | 0.84 | KDR (0.38) | KDRTRPV1MEN1KMT2ANPC1 | |
| SCHEMBL5037419 | 0.84 | MCHR1 (0.41) | KDRTRPV1NPC1RAB9A | |
| SCHEMBL5037416 | 0.84 | MCHR1 (0.41) | KDRTRPV1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1954132-A2 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | Renovis, Inc. (US) | 2008-08-13 | — | — | EP | claimed |
| WO-2007100758-A2 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | RENOVIS, INC. (US) | 2007-09-07 | — | — | WO | claimed |