Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM10 | O14672 | 20/20 | 0.48 |
| ▸ | MMP2 | P08253 | 16/20 | 0.48 |
| ▸ | MMP3 | P08254 | 5/20 | 0.47 |
| ▸ | MMP9 | P14780 | 10/20 | 0.45 |
| ▸ | MMP1 | P03956 | 3/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 7/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5044734 | 0.88 | ADAM10 (0.61) | ADAM10MMP2MMP3MMP9MMP1 | |
| SCHEMBL5039619 | 0.88 | ADAM10 (0.61) | ADAM10MMP2MMP3MMP9MMP1 | |
| SCHEMBL5038686 | 0.87 | ADAM10 (0.63) | ADAM10MMP2MMP3MMP9MMP1 | |
| SCHEMBL5038505 | 0.87 | ADAM10 (0.63) | ADAM10MMP2MMP3MMP9MMP1 | |
| SCHEMBL5039649 | 0.84 | ADAM10 (0.64) | ADAM10MMP2MMP3MMP9MMP1 | |
| SCHEMBL5038844 | 0.84 | ADAM10 (0.60) | ADAM10MMP2MMP3MMP9MMP1 | |
| SCHEMBL5044852 | 0.84 | ADAM10 (0.61) | ADAM10MMP2MMP3MMP9MMP1 | |
| SCHEMBL5038829 | 0.83 | ADAM10 (0.49) | ADAM10MMP2MMP3MMP9MMP1 | |
| SCHEMBL5038217 | 0.83 | ADAM10 (0.47) | ADAM10MMP2MMP3MMP9MMP1 | |
| SCHEMBL5042911 | 0.83 | ADAM10 (0.63) | ADAM10MMP2MMP3MMP9MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1622569-A4 | AZA SPIRO ALKANE DERIVATIVES AS INHIBITORS OF METALLPROTEASES | INCYTE CORP (US) | 2008-08-27 | — | — | EP | claimed |
| EP-1622569-A2 | AZA SPIRO ALKANE DERIVATIVES AS INHIBITORS OF METALLPROTEASES | Incyte Corporation (US) | 2006-02-08 | — | — | EP | claimed |
| WO-2004096139-A2 | AZA SPIRO ALKANE DERIVATIVES AS INHIBITORS OF METALLOPROTEASES | INCYTE CORPORATION (US) | 2004-11-11 | — | — | WO | claimed |