Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHPS | P49366 | 16/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14278703 | 0.87 | SYK (0.38) | DHPS | |
| SCHEMBL6179294 | 0.85 | DHPS (0.41) | DHPS | |
| SCHEMBL4061462 | 0.79 | DHPS (0.49) | DHPS | |
| SCHEMBL28568819 | 0.78 | DHPS (0.59) | DHPS | |
| SCHEMBL5039291 | 0.77 | DHPS (0.49) | DHPS | |
| SCHEMBL1937757 | 0.76 | EDNRA (0.49) | DHPS | |
| SCHEMBL5032721 | 0.74 | DHPS (0.49) | DHPS | |
| SCHEMBL5036194 | 0.73 | EDNRA (0.77) | — | |
| SCHEMBL9423634 | 0.73 | FFAR1 (0.51) | — | |
| SCHEMBL5039297 | 0.73 | DHPS (0.61) | DHPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0979822-B1 | Process for the preparation of 2-carbamoyl-pyridines | HOFFMANN LA ROCHE (CH) | 2005-11-30 | — | — | EP | claimed |
| US-6103902-A | Carbamoylation process | HOFFMANN-LA ROCHE INC. (US) | 2000-08-15 | — | — | US | claimed |
| EP-0979822-A1 | Process for the preparation of 2-carbamoyl-pyridines | F. HOFFMANN-LA ROCHE AG (CH) | 2000-02-16 | — | — | EP | claimed |
| EP-1149091-B1 | 4-(HETEROCYCLYLSULFONAMIDO)-5-METHOXY-6-(2-METHOXYPHENOXY)-2-PHENYL- OR PYRIDYLPYRIMIDINES AS ENDOTHELIN RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2008-03-19 | — | — | EP | disclosed |
| EP-0979822-B1 | Process for the preparation of 2-carbamoyl-pyridines | HOFFMANN LA ROCHE (CH) | 2005-11-30 | — | — | EP | disclosed |
| EP-1149091-A1 | 4-(HETEROCYCLYLSULFONAMIDO)-5-METHOXY-6-(2-METHOXYPHENOXY)-2-PHENYL- OR PYRIDYLPYRIMIDINES AS ENDOTHELIN RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-10-31 | — | — | EP | disclosed |
| US-6242601-B1 | ENDOTHELIN RECEPTORS INHIBITORS SUCH AS 4-(4-METHOXY-5-(2-METHOXY-PHENOXY)-6-(5-METHYL-PYRIDINE-2-SULF ONYLAMINO)-PYRIMIDIN-2-YL)-PYRIDINE-2-CARBOXYLIC ACID USED TO TREAT CARDIOVASCULAR SYSTEM DISORDERS | HOFFMAN-LA ROCHE INC. | 2001-06-05 | — | — | US | disclosed |
| US-6103902-A | Carbamoylation process | HOFFMANN-LA ROCHE INC. (US) | 2000-08-15 | — | — | US | disclosed |
| WO-2000042035-A1 | 4-(HETEROCYCLYLSULFONAMIDO) -5-METHOXY-6- (2-METHOXYPHENOXY) -2-PHENYL- OR PYRIDYLPYRIMIDINES AS ENDOTHELIN RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-07-20 | — | — | WO | disclosed |
| JP-2000063377-A | PRODUCTION OF SUBSTITUTED PYRIDINE | F HOFFMANN LA ROCHE AG | 2000-02-29 | — | — | JP | disclosed |
| EP-0979822-A1 | Process for the preparation of 2-carbamoyl-pyridines | F. HOFFMANN-LA ROCHE AG (CH) | 2000-02-16 | — | — | EP | disclosed |