Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.45 |
| ▸ | CFTR | P13569 | 1/20 | 0.45 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.45 |
| ▸ | KCNA5 | P22460 | 4/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | FDPS | P14324 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL884430 | 0.81 | KCNA5 (0.61) | SLC6A2SLC6A4SLC6A3CFTRGOPC | |
| SCHEMBL5038329 | 0.80 | KCNA5 (0.62) | SLC6A2SLC6A4SLC6A3CFTRGOPC | |
| SCHEMBL31570747 | 0.79 | SLC6A2 (0.66) | SLC6A2SLC6A4SLC6A3CFTRGOPC | |
| SCHEMBL31570740 | 0.78 | GAA (0.55) | SLC6A2SLC6A4SLC6A3CFTRGOPC | |
| SCHEMBL2062646 | 0.75 | KCNA5 (0.65) | SLC6A2SLC6A4SLC6A3CFTRGOPC | |
| SCHEMBL884905 | 0.74 | KCNA5 (0.51) | SLC6A2SLC6A4SLC6A3CFTRGOPC | |
| SCHEMBL11737361 | 0.73 | GAA (0.66) | SLC6A2SLC6A4SLC6A3CFTRGOPC | |
| SCHEMBL9591930 | 0.73 | SMN1; SMN2 (0.53) | SLC6A2SLC6A4SLC6A3CFTRGOPC | |
| SCHEMBL2063857 | 0.73 | KCNA5 (0.47) | SLC6A2SLC6A4SLC6A3CFTRGOPC | |
| SCHEMBL11798962 | 0.73 | SMN1; SMN2 (0.56) | SLC6A2SLC6A4SLC6A3CFTRGOPC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940406-A2 | POTASSIUM CHANNEL INHIBITORS | Merck and Co., Inc. (US) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007050348-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2007-05-03 | — | — | WO | disclosed |