Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 8/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.44 |
| ▸ | CFTR | P13569 | 1/20 | 0.44 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5038329 | 0.96 | KCNA5 (0.62) | KCNA5KCNH2HTTKMT2ASLC6A2 | |
| SCHEMBL5035444 | 0.81 | SLC6A2 (0.45) | KCNA5KCNH2HTTSLC6A2SLC6A4 | |
| SCHEMBL7381762 | 0.81 | KMT2A (0.48) | KCNA5KCNH2HTTKMT2ACYP11B1 | |
| SCHEMBL884569 | 0.79 | KCNA5 (0.51) | KCNA5KCNH2CYP11B1CYP11B2 | |
| SCHEMBL5038360 | 0.79 | KCNA5 (0.48) | KCNA5KCNH2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL884905 | 0.79 | KCNA5 (0.51) | KCNA5KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5033715 | 0.78 | KCNA5 (0.50) | KCNA5KCNH2HTTSLC6A2SLC6A4 | |
| SCHEMBL31570747 | 0.78 | SLC6A2 (0.66) | KCNA5KCNH2HTTSLC6A2SLC6A4 | |
| SCHEMBL31570740 | 0.77 | GAA (0.55) | KCNH2HTTSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2062779 | 0.76 | KCNA5 (1.00) | KCNA5KCNH2KMT2ASLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940406-A2 | POTASSIUM CHANNEL INHIBITORS | Merck and Co., Inc. (US) | 2008-07-09 | — | — | EP | claimed |
| WO-2007050348-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2007-05-03 | — | — | WO | claimed |