Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM10 | O14672 | 15/20 | 0.44 |
| ▸ | MMP2 | P08253 | 15/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.44 |
| ▸ | MMP9 | P14780 | 10/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 6/20 | 0.36 |
| ▸ | MMP12 | P39900 | 2/20 | 0.36 |
| ▸ | MMP14 | P50281 | 2/20 | 0.36 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.36 |
| ▸ | ADAM33 | Q9BZ11 | 2/20 | 0.36 |
| ▸ | ADAM8 | P78325 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 4/20 | 0.36 |
| ▸ | MMP7 | P09237 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
| ▸ | ADAM9 | Q13443 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4537261 | 0.84 | ADAM10 (0.60) | ADAM10MMP2ERBB2MMP9MMP3 | |
| SCHEMBL4530938 | 0.84 | ADAM10 (0.60) | ADAM10MMP2ERBB2MMP9MMP3 | |
| SCHEMBL5038740 | 0.82 | ADAM10 (0.49) | ADAM10MMP2ERBB2MMP9MMP3 | |
| SCHEMBL5045388 | 0.82 | ADAM10 (0.49) | ADAM10MMP2ERBB2MMP9MMP3 | |
| SCHEMBL5038352 | 0.81 | ADAM10 (0.47) | ADAM10MMP2ERBB2MMP9MMP3 | |
| SCHEMBL17743489 | 0.81 | ADAM10 (0.47) | ADAM10MMP2ERBB2MMP9MMP3 | |
| SCHEMBL1365344 | 0.80 | ADAM10 (0.71) | ADAM10MMP2ERBB2MMP9MMP3 | |
| SCHEMBL5035330 | 0.80 | ADAM10 (0.53) | ADAM10MMP2ERBB2MMP9MMP3 | |
| SCHEMBL5038031 | 0.79 | ADAM10 (0.42) | ADAM10MMP2ERBB2MMP9MMP3 | |
| SCHEMBL5037490 | 0.77 | ADAM10 (0.52) | ADAM10MMP2ERBB2MMP9MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1622569-A4 | AZA SPIRO ALKANE DERIVATIVES AS INHIBITORS OF METALLPROTEASES | INCYTE CORP (US) | 2008-08-27 | — | — | EP | claimed |
| EP-1622569-A2 | AZA SPIRO ALKANE DERIVATIVES AS INHIBITORS OF METALLPROTEASES | Incyte Corporation (US) | 2006-02-08 | — | — | EP | claimed |
| WO-2004096139-A2 | AZA SPIRO ALKANE DERIVATIVES AS INHIBITORS OF METALLOPROTEASES | INCYTE CORPORATION (US) | 2004-11-11 | — | — | WO | claimed |