SCHEMBL5035574

SCHEMBL5035574

N#CC1CNc2ccccc2C1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MTNR1A P48039 1/20 0.41
MTNR1B P49286 1/20 0.41
EPHX2 P34913 1/20 0.39
MEN1 O00255 1/20 0.37
KMT2A Q03164 1/20 0.37
ALOX15 P16050 1/20 0.37
HSD17B10 Q99714 1/20 0.37
GAA P10253 2/20 0.36
MAPT P10636 1/20 0.36
BRD4 O60885 1/20 0.35
CREBBP Q92793 1/20 0.35
ALDH1A1 P00352 1/20 0.34
CYP1A2 P05177 1/20 0.33
CYP11B1 P15538 1/20 0.33
CYP11B2 P19099 1/20 0.33
TSHR P16473 1/20 0.32
AR P10275 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
CHRNB2 P17787 1/20 0.31
CHRNA4 P43681 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7052735 0.81 MTNR1A (0.44) MTNR1AMTNR1BEPHX2MEN1KMT2A
SCHEMBL30479659 0.77 CYP1A2 (0.39) CYP1A2CYP11B1CYP11B2CHRNB2CHRNA4
SCHEMBL30887799 0.77 CYP1A2 (0.39) CYP1A2CYP11B1CYP11B2CHRNB2CHRNA4
SCHEMBL1415621 0.75 IDO1 (0.41) CYP1A2CYP11B1CYP11B2
SCHEMBL29539739 0.75 IDO1 (0.41) CYP1A2CYP11B1CYP11B2
SCHEMBL3825586 0.71 PLAU (0.45) MTNR1AMTNR1BEPHX2MEN1KMT2A
SCHEMBL4014104 0.71 MTNR1A (0.44) MTNR1AMTNR1BEPHX2MEN1KMT2A
SCHEMBL2152470 0.71 MTNR1A (0.47) MTNR1AMTNR1BEPHX2MEN1KMT2A
SCHEMBL15265894 0.71 MTNR1A (0.47) MTNR1AMTNR1BEPHX2MEN1KMT2A
SCHEMBL9965445 0.71 BRD4 (0.55) MTNR1AMTNR1BEPHX2MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022155419-A1 INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS ESCAPE Bio, Inc. (US) 2022-07-21 WO disclosed
WO-2021178780-A1 INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS ESCAPE Bio, Inc. (US) 2021-09-10 WO disclosed
CN-110072864-A TDO2 INHIBITORS 基因泰克公司 2019-07-30 CN disclosed
EP-3224258-A1 4,5,6,7-TETRAHYDRO-1 H-PYRAZOLO[4,3-C]PYRIDIN-3-AMINE COMPOUNDS AS CBP AND/OR EP300 INHIBITORS Genentech, Inc. (US) 2017-10-04 EP disclosed
CN-104583197-B New bicyclicpyridine derivatives 霍夫曼-拉罗奇有限公司 2017-05-17 CN disclosed
WO-2016086200-A1 4,5,6,7-TETRAHYDRO-1 H-PYRAZOLO[4,3-C]PYRIDIN-3-AMINE COMPOUNDS AS CBP AND/OR EP300 INHIBITORS GENENTECH, INC. (US) 2016-06-02 WO disclosed
CN-103391928-B 1, 4-oxaza as BACE1 and/or BACE2 inhibitors HOFFMAN-LA ROCHE LTD. (CH) 2015-11-25 CN disclosed
EP-2888245-A1 NEW BICYCLICPYRIDINE DERIVATIVES F. Hoffmann-La Roche AG (CH) 2015-07-01 EP disclosed
WO-2014029723-A1 NEW BICYCLICPYRIDINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2014-02-27 WO disclosed
CN-103534243-A 1, 3-oxazines as BACE1 and/or BACE2 inhibitors HOFFMANN LA ROCHE 2014-01-22 CN disclosed
EP-2686307-A1 1,4-OXAZEPINES AS BACE1 AND/OR BACE2 INHIBITORS F.HOFFMANN-LA ROCHE AG (CH) 2014-01-22 EP disclosed
CN-103391928-A 1, 4-oxaza as BACE1 and/or BACE2 inhibitors HOFFMANN LA ROCHE 2013-11-13 CN disclosed
CN-103391924-A Novel antiviral compounds UNIV LEUVEN KATH 2013-11-13 CN disclosed
WO-2012126791-A1 1,4-OXAZEPINES AS BACE1 AND/OR BACE2 INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2012-09-27 WO disclosed
EP-1723116-B1 TETRAHYDROQUINOLINONES AND THEIR USE AS ANTAGONISTS OF METABOTROPIC GLUTAMATE RECEPTORS MERZ PHARMA GMBH & CO KGAA (DE) 2008-09-24 EP disclosed