Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 8/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.34 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.34 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5041456 | 0.93 | CYP3A4 (0.48) | CYP3A4KMT2AMEN1L3MBTL1KDM4E | |
| SCHEMBL5032683 | 0.91 | CYP3A4 (0.37) | CYP3A4KMT2AMEN1CYP1A2CYP2D6 | |
| SCHEMBL5032460 | 0.90 | CYP3A4 (0.46) | CYP3A4KMT2AMEN1CYP1A2CYP2D6 | |
| SCHEMBL5032505 | 0.85 | CYP3A4 (0.48) | CYP3A4KMT2AMEN1CYP1A2CYP2D6 | |
| SCHEMBL5032642 | 0.84 | CYP3A4 (0.41) | CYP3A4KMT2AMEN1CYP1A2CYP2D6 | |
| SCHEMBL5035001 | 0.83 | CYP3A4 (0.41) | CYP3A4KMT2AMEN1HTTALDH1A1 | |
| SCHEMBL5034877 | 0.81 | CYP3A4 (0.44) | CYP3A4KMT2AMEN1CYP1A2CYP2D6 | |
| SCHEMBL5035060 | 0.80 | CYP3A4 (0.42) | CYP3A4KMT2AMEN1CYP1A2CYP2D6 | |
| SCHEMBL5032621 | 0.79 | CYP3A4 (0.53) | CYP3A4CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL5034781 | 0.79 | CYP3A4 (0.42) | CYP3A4KMT2AMEN1HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1694673-B1 | THIAZOLE DERIVATES | HOFFMANN LA ROCHE (CH) | 2008-01-16 | — | — | EP | claimed |